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The conventional mental implants suffer from mechanical strength mismatch and long\u2010term foreign bodies presence. While, the osteoinductive materials lack insufficient mechanical strength for the repair of load\u2010bearing bone. Inspired by bamboo, whisker\u2010reinforced Ca\u2010P ceramics (HW) have been developed to accelerate segmental bone regeneration. Bamboo\u2010like whiskers can reduce the stress concentration and impede crack propagation via whisker broken, whisker bridging, and crack deflection, achieving 3 times increase in the compressive strength compared to traditional ceramics. In addition, HW significantly promotes the formation of type\u2010H endothelial cells (ECs) via the integrin\u2010mediated HIF\u20101 signaling pathway, which can secrete coupling factors (e.g. Noggin), to promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In turn, HW can stimulate BMSCs to secrete coupling factors (e.g. VEGF) to support angiogenesis. In the segmental bone defect model, DFO is introduced to bamboo\u2010like whiskers (HW+DFO) to enhance type\u2010H vessels formation. HW+DFO can effectively promote the repair of segmental bone defects with mechanical recovery reaching 40% of that of normal femur. In conclusion, this study proposes a novel strategy for promoting bone regeneration by regulating type\u2010H vessels, offering a potential solution for addressing segmental bone defects.<\/jats:p>","DOI":"10.1002\/advs.75178","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:19:06Z","timestamp":1775557146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bamboo\u2010Like Whiskers\u2010Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type\u2010H Vessels and Osteoinduction"],"prefix":"10.1002","volume":"13","author":[{"given":"Cong","family":"Feng","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Teng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyao","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaze","family":"He","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keting","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-9900","authenticated-orcid":false,"given":"Xiangfeng","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-3333","authenticated-orcid":false,"given":"Jianguo","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Department of Neurosurgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS\u2010D\u201014\u201000018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2015.05.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad5904"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.09.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010020\u20100204\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001115"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.11.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014153\u20107"},{"key":"e_1_2_10_10_1","volume-title":"Definitions of Biomaterials for the Twenty\u2010First Century Amsterdam","author":"Zhang X. 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