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While dECM provides cell\u2010adhesive and protease\u2010labile sequences to support cell\u2010matrix interactions, its crosslinking into hydrogels has been largely limited to temperature\u2010induced gelation, which offers limited tunability. To address this challenge, we previously reported the synthesis of bovine decellularized SIS\u2010norbornene (dSIS\u2010NB) for crosslinking into cytocompatible thiol\u2010norbornene hydrogels with pro\u2010angiogenic and pro\u2010vasculogenic properties. In this study, we conducted proteomic profiling to analyze the protein compositions of bovine dSIS and dSIS\u2010NB. In addition to various collagens, we discovered that bovine dSIS contained significant amounts of fibrillin\u2010I, a glycoprotein stabilized by intra\u2010 and inter\u2010molecular disulfide bonds. We leveraged these disulfide bonds to fabricate \u2018self\u2010clickable\u2019 dSIS\u2010NB thiol\u2010norbornene hydrogels without the need for additional thiol\u2010bearing crosslinker (e.g., 4\u2010arm poly(ethylene glycol)\u2010thiol). Furthermore, we exploited thiol\u2010disulfide exchange in self\u2010clickable dSIS\u2010NB hydrogels to enable light\u2010induced spatiotemporal tuning of hydrogel stiffness and labeling of bioactive ligands. Finally, the dynamic and self\u2010clickable dSIS\u2010NB hydrogels were used as an in vitro cell culture model to study local vascular compression and as an injectable, cell\u2010laden matrix to treat volumetric muscle loss.<\/jats:p>","DOI":"10.1002\/advs.75296","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:46:07Z","timestamp":1776685567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Self\u2010Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Van Thuy","family":"Duong","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Marjan","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Ha","family":"Luong","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-9170","authenticated-orcid":false,"given":"Taimoor H.","family":"Qazi","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-8796","authenticated-orcid":false,"given":"Chien\u2010Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Administration U. 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