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Herbivorous insects pose a significant threat to global agriculture. While plants deploy defense hormones like jasmonic acid (JA) and salicylic acid (SA), the role of beneficial microbes in enhancing these defenses remains underexplored. This study unveils a novel tripartite interaction in which cotton actively mobilizes the soil\u2010derived bacterium\n                    <jats:italic>Delftia tsuruhatensis<\/jats:italic>\n                    to roots and leaves upon aphid attack, reshaping its microbiome for defense. Following aphid infestation, the abundance of\n                    <jats:italic>D. tsuruhatensis<\/jats:italic>\n                    was increased significantly in both roots and leaves. Inoculation of cotton with\n                    <jats:italic>D. tsuruhatensis<\/jats:italic>\n                    significantly reduced aphid fitness, inhibiting phloem feeding, decreasing survival, prolonging nymphal development, and impairing reproduction. Mechanistically, we found that\n                    <jats:italic>D. tsuruhatensis<\/jats:italic>\n                    activates the host plant's SA signaling pathway. This plant\u2010mediated response, in turn, effectively suppresses the expression of a key aphid detoxification gene,\n                    <jats:italic>UGT2B17<\/jats:italic>\n                    (\n                    <jats:italic>UDP\u2010glucosyltransferase 2B17<\/jats:italic>\n                    ), compromising the insect's ability to metabolize plant defenses. Furthermore, the combination of\n                    <jats:italic>D. tsuruhatensis<\/jats:italic>\n                    and RNAi\u2010mediated silencing of\n                    <jats:italic>UGT2B17<\/jats:italic>\n                    synergistically enhanced aphid mortality. Our results elucidate a sophisticated defense strategy wherein the host plant leverages a beneficial microbe to augment its innate immunity through cross\u2010kingdom gene regulation, ultimately disarming the pest's detoxification system.\n                  <\/jats:p>","DOI":"10.1002\/advs.75321","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:29:38Z","timestamp":1776680978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cotton Recruits Soil\u2010Derived\n                    <i>Delftia tsuruhatensis<\/i>\n                    to Suppress Aphid Detoxification Via Salicylic Acid\u2010Mediated Defense"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-9782","authenticated-orcid":false,"given":"Hui","family":"Xue","sequence":"first","affiliation":[{"name":"Research Base of Zhengzhou University, State Key Laboratory of Cotton 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Institute of Cotton Research Chinese Academy of Agricultural Sciences  Anyang Henan China"},{"name":"College of Plant Science and Technology Huazhong Agricultural University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Base of Zhengzhou University, State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization Institute of Cotton Research Chinese Academy of Agricultural Sciences  Anyang Henan China"},{"name":"State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization, School of Agricultural Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Research Base of Zhengzhou University, State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization Institute of Cotton Research Chinese Academy 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Anyang Henan China"},{"name":"State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization, School of Agricultural Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Research Base of Zhengzhou University, State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization Institute of Cotton Research Chinese Academy of Agricultural Sciences  Anyang Henan China"},{"name":"State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization, School of Agricultural Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Cui","sequence":"additional","affiliation":[{"name":"Research Base of Zhengzhou University, State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization Institute of Cotton Research Chinese Academy of Agricultural 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