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To address the issues, this study developed a smart drug\u2010release coating based on a superhydrophobic\u2010wettable transition mechanism. The coating on the abutment surface was constructed by hydrophobic micelles self\u2010assembling on mesoporous silica nanoparticles loaded with berberine. In the early stage, the superhydrophobic surface can effectively resist the adhesion of proteins and bacteria. With protein deposition, this process induced a transition of the superhydrophobic surface to a hydrophilic state, leading to a sigmoidal drug release profile that passively triggered sustained microenvironment regulation in the later stage. In vivo experiments demonstrated that this coating not only had strong immediate antibacterial efficacy (22.5\u2010fold enhancement) but also significantly reduced inflammation and promoted soft tissue closure. This work provides a sequential functionalization strategy of \u201cearly\u2010antifouling\u2010enabled late active regulation\u201d for abutments, offering a potential solution to prevent peri\u2011implant inflammation and soft tissue dehiscence.<\/jats:p>","DOI":"10.1002\/advs.75351","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:15:06Z","timestamp":1776366906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interface Wettability Transition\u2010Driven Drug Release and Dual\u2010Phase Functionalization in Implant Abutment"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhongchao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontics &amp; Oral Mucosal Diseases The Affiliated Stomatological Hospital Southwest Medical University  Luzhou Sichuan China"},{"name":"Luzhou Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration  Luzhou Sichuan China"},{"name":"Institute of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Luzhou Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration  Luzhou Sichuan China"},{"name":"Institute of Stomatology Southwest Medical University  Luzhou Sichuan China"},{"name":"Department of Prosthodontics The Affiliated Stomatological Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MingXia","family":"Li","sequence":"additional","affiliation":[{"name":"Luzhou Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration  Luzhou Sichuan China"},{"name":"Institute of Stomatology Southwest Medical University  Luzhou Sichuan China"},{"name":"Department of Oral Radiology The Affiliated Stomatological Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-4970","authenticated-orcid":false,"given":"Xiao","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China  Chengdu P. 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