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The nanoprobe exhibits enhanced near\u2010infrared photoluminescence performance while enabling efficient photothermal conversion, photodynamic effect, photoacoustic imaging, and magnetic resonance imaging enhancement. Theoretical simulations demonstrate that the local surface plasmon resonance effect of gold nanorods exerts a significant enhancement on the optical performance of nanoprobes. Moreover, metal atoms play a pivotal role in modulating excited states and enhancing the intersystem crossing of indocyanine green. In vitro experiments confirm that the nanoprobe exhibits favorable biocompatibility and tumor\u2010targeting capacity; under 808\u00a0nm laser irradiation, it enables synergistic therapy by generating reactive oxygen species and inducing hyperthermia, with the mechanism underlying synergistic treatment elucidated from both physical and biological perspectives. The nanoprobe facilitates near\u2010infrared photo\u2010magnetic\u2010acoustic\u2010thermal multimodal imaging, achieves efficient photothermal\u2010photodynamic synergistic therapy on tumor\u2010xenografted mice upon the laser irradiation, exerts effective inhibition on tumor growth, and mitigates tumor recurrence by inducing immunogenic cell death. This study offers insights into the design of novel high\u2010performance optical nanoprobes and highlights the application potential of this nanoprobe in the precise diagnosis and synergistic treatment of nasopharyngeal carcinoma.<\/jats:p>","DOI":"10.1002\/advs.75357","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:25:12Z","timestamp":1776367512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dumbbell\u2010Structured Plasmonic\u2010Enhanced Optical Nanoprobes Boosting Photo\u2010Magnetic\u2010Acoustic Multimodal Imaging\u2010Guided Photodynamic\u2010Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Baikang","family":"Zhuang","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National\u2010Regional Key Technology 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