{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:32:32Z","timestamp":1786447952955,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1700303"],"award-info":[{"award-number":["2023YFD1700303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21808059"],"award-info":[{"award-number":["21808059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Trifluoromethyl ketones are valuable scaffolds in drug discovery and material science, but their synthesis is often hindered by the need for prefunctionalized substrates, harsh oxidative conditions, and expensive trifluoromethylating reagents. To address these challenges, a continuous\u2010flow heterogeneous photocatalytic trifluoromethylation strategy is developed to synthesize\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010trifluoromethyl\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010aryl ketones via visible\u2010light\u2010induced 1,2\u2010aryl migration. Mesoporous graphitic carbon nitride (\n                    <jats:italic>mpg<\/jats:italic>\n                    \u2010C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    ) is employed as a recyclable photocatalyst, and trifluoromethanesulfonyl chloride (TfCl) serves as an affordable CF\n                    <jats:sub>3<\/jats:sub>\n                    source, enabling a mild and sustainable radical pathway. The reaction is conducted in a continuous oscillatory flow system integrated with a custom photoreactor, ensuring efficient light utilization and stable catalyst handling. For the model substrate, an 83% isolated yield is achieved within 30 min, corresponding to a space\u2010time yield of 6.95 g\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    , significantly surpassing that obtained under batch conditions (0.36 g\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    with 43% isolated yield in 12 h). The method shows broad substrate compatibility, obtaining\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010trifluoromethyl\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010aryl ketones in 54%\u201388% yields from 23 allyl alcohols. The scalability is confirmed with a gram\u2010scale preparation, and the intermediate is converted into a bioactive molecule via an integrated multi\u2010step continuous\u2010flow process. This work provides a sustainable, efficient strategy for synthesizing fluorinated compounds of pharmaceutical relevance.\n                  <\/jats:p>","DOI":"10.1002\/advs.75371","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:48:43Z","timestamp":1776854923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous Visible\u2010Light Photocatalysis in Continuous\u2010Flow: A Synergistic Strategy for Challenging Trifluoromethylation of\n                    <i>\u03b1, \u03b1<\/i>\n                    \u2010Diaryl Allylic Alcohols via 1,2\u2010aryl Migration"],"prefix":"10.1002","volume":"13","author":[{"given":"Peiwen","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy East China Normal University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China Normal University  Shanghai P. R. China"},{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-7729","authenticated-orcid":false,"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China Normal University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01698"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1001482"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1013693"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60274a001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00794"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4002879"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131943"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201202624"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.05.078"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b00940"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.11.033"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900391x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2017.12.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2007.07.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-04164-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/352760393X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302376"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b00156"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol502071g"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302673"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43936d"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2015.08.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201500096"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912450"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201800726"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC01189B"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2009.05.083"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202300723"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol403650y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC01982B"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo5016757"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ceat.201500195"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR03656F"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA08871B"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002465"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405902"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123134"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.18553"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RE00036A"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41981-020-00105-6"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.8b00446"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109020"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164978"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.3c00176"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0209230"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0210562"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:50:11Z","timestamp":1786445411000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":46,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.75371"],"URL":"https:\/\/doi.org\/10.1002\/advs.75371","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75371"}}