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However, in lignocellulosic biorefinery, cross\u2010interference between cellulose, hemicellulose, and lignin persists throughout all steps. Effective regulation must extend beyond pretreatment across the entire process. Here, we develop a whole\u2010process regulation strategy for corn stover. Mechanical fractionation homogenizes physical structure, yielding parenchyma\u2010rich short fibers and vascular\u2010bundle\u2010dominant long fibers. For highly degradable short fibers, molecular control by methanol during steam explosion suppresses lignin condensation, followed by oxidative enhancement by carbon quantum dots during enzymatic hydrolysis, boosting cellulose conversion and facilitating mild lignin depolymerization for high\u2010performance epoxy resins. For high\u2010crystallinity long fibers, two\u2010stage selective enzymatic hydrolysis preserves crystallinity to produce cellulose nanocrystals. Techno\u2010economic analysis shows a 36.7% revenue increase over the unregulated baseline. This integrated approach embodies the concept of precision biorefinery: a transformative framework where whole\u2010process regulation orchestrates multi\u2010level heterogeneity\u2010guided fractionation to enable full\u2010component directed valorization, ensuring compatibility between biomass attributes, process, and product specifications. The concept and innovations have been industrially validated.<\/jats:p>","DOI":"10.1002\/advs.75391","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:57:26Z","timestamp":1779958646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision Lignocellulosic Biorefinery: Process Regulation From Corn Stover to Products"],"prefix":"10.1002","volume":"13","author":[{"given":"Xue\u2010Cheng","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Beijing Key Laboratory of Biomass Refining Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing China"},{"name":"School of Advanced Interdisciplinary Sciences University of Chinese Academy of Sciences  Beijing 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