{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:32:54Z","timestamp":1786447974567,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371654"],"award-info":[{"award-number":["82371654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571901"],"award-info":[{"award-number":["82571901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometriosis (EMs) features ectopic implantation of endometrial stromal cells (EESCs) and strong anoikis resistance, yet how inflammatory signals reprogram mitochondrial function remains unclear. Here, neutrophil extracellular traps (NETs), particularly their DNA scaffold (NET\u2010DNA), are identified as enriched in early lesions and associated with enhanced mitophagy and EESCs survival. In primary human EESCs, NET\u2010DNA suppresses anoikis, increases mitochondrial membrane potential, decreases reactive oxygen species, and enhances ER\u2013mitochondria contacts. NET\u2010DNA directly binds Annexin A2 (ANXA2), promotes its redistribution from the plasma membrane to the cytoplasm, and independently upregulates the ER\u2010resident transmembrane protein TMEM215. TMEM215 facilitates formation of a Ca2+\u2010dependent ANXA2\u2013TMEM215 complex, enhancing ER\u2013mitochondria contacts and PINK1\/Parkin\u2010mediated mitophagy. Silencing ANXA2 or TMEM215 disrupts mitophagy, impairs mitochondrial Ca2+ handling, reduces ER\u2013mitochondria contacts, and restores anoikis sensitivity. Proteomic analysis identifies Binding Immunoglobulin Protein (BiP\/GRP78) as a TMEM215\u2010interacting partner, and NET\u2010DNA promotes assembly of a TMEM215\u2013ANXA2\u2013BiP complex that reinforces mitochondrial quality control. In mouse EMs models, knockdown of TMEM215 or ANXA2 reduces lesion growth and partially reverses LPS\u2010associated progression. These findings reveal a mechanism linking inflammation to mitochondrial reprogramming in EMs and suggest a potential therapeutic target.<\/jats:p>","DOI":"10.1002\/advs.75442","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:57:17Z","timestamp":1777276637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NET\u2010DNA Activates the ANXA2\/TMEM215\/BiP Axis to Promote Mitophagy\u2010Mediated Anoikis Resistance in Endometriosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Honglin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-7542","authenticated-orcid":false,"given":"Beidi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruru","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-1290","authenticated-orcid":false,"given":"Zongfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700089"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2975"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt027"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002647"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathmechdis\u2010012419\u2010032654"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010070750"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.041"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad020"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000242"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.718"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101099"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010020\u201000421\u20101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz018"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.186133"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S504327"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118757682"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001683\u2010x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408220"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201002981\u20102"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2025.09.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.06.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae584"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010025\u201000944\u20103"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.001"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500781"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00062.2021"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108328"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.10.040"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201023\u20102986"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00670"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102394\u20106"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001500\u20105"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201000988\u20101"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2021"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158448"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119876"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104705"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122484"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105074"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14080919"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.07.019"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102906"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001497\u20102"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601078"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404275"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.125321"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307118120"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010023\u201002616\u20101"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001881\u20106"},{"issue":"6","key":"e_1_2_11_54_1","first-page":"1167","article-title":"Diastolic Pressure Volume Behavior in Frog Ventricles Under Excessive Calcium Supply and Lack of Oxygen","volume":"26","author":"Koall B.","year":"1971","journal-title":"Acta Biol Med Ger"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322686"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108366"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:50:47Z","timestamp":1786445447000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":55,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.75442"],"URL":"https:\/\/doi.org\/10.1002\/advs.75442","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75442"}}