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Extracellular vesicles (EVs) hold considerable promise as therapeutics for cardiovascular disorders. However, the targeted delivery of them to the heart has received relatively limited research. Acute MI is often accompanied by severe inflammation. After MI, numbers of monocytes\/macrophages are rapidly mobilized from the circulation and accumulate within the ischemic myocardial tissue. This recruitment is driven by the inflammatory homing signals emanating from the injured cardiac region. In this work, we develop a biomimetic nanovesicle by fusing membranes isolated from bone marrow mononuclear cells (Mon) with extracellular vesicles derived from healthy human plasma (M\u2010hEV). This biomimetic delivery platform achieves site\u2010specific accumulation at damaged vascular endothelial cells and cardiomyocytes by leveraging two key molecular recognition mechanisms: the monocyte chemoattractant protein\u20101 (MCP\u20101)\/C\u2010C chemokine receptor 2 (CCR2) and intercellular adhesion molecule\u20101 (ICAM\u20101)\/CD11b axes. The results indicate that M\u2010hEV can inhibit apoptosis of vascular endothelial cells and cardiomyocytes, promote angiogenesis and regulate macrophage polarization at the cellular and animal levels. Furthermore, M\u2010hEV can home to the MI heart, reduce the infarct size, reduce the inflammation level, and improve cardiac function. This biomimetic system provides a novel approach to explore new targeted drugs for MI treatment.<\/jats:p>","DOI":"10.1002\/advs.75445","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:54:07Z","timestamp":1777280047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Bone Marrow Monocyte Membrane\u2010Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiaxin","family":"Song","sequence":"first","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"},{"name":"Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ Repair School of Life Science Joint 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