{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:11:11Z","timestamp":1788869471977,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090024"],"award-info":[{"award-number":["82090024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173877"],"award-info":[{"award-number":["82173877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60677"],"award-info":[{"award-number":["2025JJ60677"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5571"],"award-info":[{"award-number":["2024JJ5571"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Acute kidney injury (AKI) is a severe clinical condition with high morbidity and mortality. Caveolin\u20101 (Cav\u20101), a main structural protein of caveolae, orchestrates key cellular processes including endocytosis, lipid transport, and signal transduction by serving as a platform. However, its specific role in AKI remains unclear. Here, we report that Cav\u20101 is upregulated in distal tubule epithelial cells (TECs) in both AKI patients and mouse models induced by ischemia\/reperfusion injury (IRI) and lipopolysaccharide (LPS). Global and distal TEC\u2010specific\n Cav1<\/jats:italic>\n knockout exacerbates IRI and LPS\u2010induced AKI. RNA\u2010seq reveals that Cav\u20101 deficiency exacerbates intracellular calcium ion (Ca\n 2+<\/jats:sup>\n ) homeostasis imbalance and endoplasmic reticulum (ER) stress in injured kidney tissues. Mechanistically, Cav\u20101 interacts with sarcoplasmic\/endoplasmic reticulum Ca\n 2+<\/jats:sup>\n \u2010ATPase 2 (SERCA2), a key regulator of intracellular Ca\n 2+<\/jats:sup>\n homeostasis, through its scaffolding domain, promoting SERCA2 deubiquitination and stability in the ER, thereby maintaining intracellular Ca\n 2+<\/jats:sup>\n homeostasis and suppressing ER stress in distal TECs. Furthermore, supplementation with a cell\u2010permeable Cav\u20101 scaffolding domain peptide (CSP) or activation of SERCA2 with a small\u2010molecule agonist CDN1163 alleviates IRI\u2010 and LPS\u2010induced AKI, while distal TEC\u2010specific SERCA2 knockdown abrogates CSP's therapeutic effect. Together, these findings reveal a novel Cav\u20101\u2010mediated pathway and highlight its potential as a therapeutic target for AKI.\n <\/jats:p>","DOI":"10.1002\/advs.75449","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:41:26Z","timestamp":1778272886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caveolin\u20101 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca\n 2+<\/sup>\n \u2010Dependent Endoplasmic Reticulum Stress in Distal Tubules"],"prefix":"10.1002","volume":"13","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Key Laboratory of Organ Fibrosis Central South University Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 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