{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:46:27Z","timestamp":1791049587909,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Claiming 3.8 million lives annually, fungal pathogens represent a major health threat, where\n                    <jats:italic>Candida<\/jats:italic>\n                    species are the leading cause with &gt;40% mortality rates. Despite rising prevalence of life\u2010threatening fungal species\/strains, progress in developing new antifungal agents remains limited. Here, we report a new synthetic membrane\u2010active cationic supramolecule\n                    <jats:bold>Gua\u2010SMACS\u201016<\/jats:bold>\n                    that exhibits high antifungal potency and selectivity for\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    (MIC = 0.4\u20100.8\u00a0\u00b5M) without affecting other phylogenetically close species in the\n                    <jats:italic>Candida<\/jats:italic>\n                    genus, non\u2010\n                    <jats:italic>Candida<\/jats:italic>\n                    fungal, or common opportunistic bacterial species in the human microbiome.\n                    <jats:bold>Gua\u2010SMACS\u201016<\/jats:bold>\n                    exerts its activity by disrupting the cytoplasmic membrane, while its\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    selectivity is attributed to the species\u2019 low cell wall \u03b2\u2010glucan level, which fails to block the supramolecule entry. It also exhibits minimal toxicity to mammalian cells and zebrafish embryos, suggesting a high clinical translation potential. Moreover, an ultra\u2010strong synergy was observed between\n                    <jats:bold>Gua\u2010SMACS\u201016<\/jats:bold>\n                    and caspofungin, a clinical antifungal drug inhibiting 1,3\u2010\u03b2\u2010glucan synthase, reducing their MICs by orders of magnitude against all tested\n                    <jats:italic>Candida<\/jats:italic>\n                    species including the intractable\n                    <jats:italic>C. auris<\/jats:italic>\n                    . Together, this work highlights the importance of cell wall glucan for membrane\u2010active antifungal amphiphiles, provides a novel design principle for species\u2010specific antifungal agents, and uncovers a new approach to developing synergizers for combination antifungal therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.75480","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:11:08Z","timestamp":1777475468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Cationic Supramolecule With Potent Antifungal Activity, Single\u2010Species Selectivity, and Strong Synergy With Echinocandins"],"prefix":"10.1002","volume":"13","author":[{"given":"Tianjiao","family":"Dai","sequence":"first","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrielle Xianwen","family":"Chen","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve Wai Ling","family":"Chow","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Mei","family":"Pang","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Li","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"},{"name":"Singapore Eye Research Institute (SERI) The Academia  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Shekhar","family":"Verma","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"},{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"},{"name":"School of Biological Sciences Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-672X","authenticated-orcid":false,"given":"Stefan H.","family":"Oehlers","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-1425","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR IDL) Agency for Science Technology and Research (A*STAR)  Singapore Singapore"},{"name":"School of Chemistry Chemical Engineering and Biotechnology 21 Nanyang Link Nanyang Technological University  Singapore 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