{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:29:56Z","timestamp":1786476596327,"version":"build-2736575974"},"reference-count":86,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2410104"],"award-info":[{"award-number":["2022YFC2410104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370944"],"award-info":[{"award-number":["82370944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401087"],"award-info":[{"award-number":["82401087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571330"],"award-info":[{"award-number":["22571330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013047"],"award-info":[{"award-number":["2024A1515013047"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010404"],"award-info":[{"award-number":["2025A1515010404"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030211"],"award-info":[{"award-number":["2024A1515030211"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vital pulp therapy (VPT) is a conservative alternative to root canal treatment that preserves the vitality of the pulp\u2013dentin complex, yet its clinical outcomes remain inconsistent due to persistent inflammation and insufficient endogenous stem cell participation. Here, we report an injectable, aptamer\u2010functionalized porous double\u2010network hydrogel (DGDL\u2010Apt) for active pulp preservation through coordinated immune\u2013redox microenvironment reprogramming and targeted stem cell recruitment. Fabricated via an air\u2010in\u2010water emulsion strategy, the hydrogel integrates a dopamine\u2010modified gelatin methacryloyl network with a supramolecular DNA\u2013Laponite assembly, forming a mechanically robust and interconnected porous structure. Dopamine\u2010derived catechol motifs restore redox homeostasis and attenuate inflammation, promoting macrophage polarization toward a reparative M2 phenotype. Meanwhile, sustained release of Laponite\u2010derived ions enhances odontogenic differentiation, and CD29\u2010targeting aptamers enable precise in situ recruitment of endogenous dental pulp stem cells. The DGDL\u2010Apt hydrogel suppresses oxidative stress, reprograms macrophage phenotype, and promotes odontogenic differentiation in vitro. In a pulpitis rat model, it achieves rapid inflammation resolution, efficient stem cell enrichment, and formation of a continuous reparative dentin bridge. This work advances VPT from passive pulp\u2010capping toward an active regenerative strategy and provides a general design principle for microenvironment\u2010driven tissue preservation.<\/jats:p>","DOI":"10.1002\/advs.75497","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:27:02Z","timestamp":1778153222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aptamer\u2010Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis"],"prefix":"10.1002","volume":"13","author":[{"given":"Luhui","family":"Cai","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Ni","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Chen","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-7649","authenticated-orcid":false,"given":"Weichang","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-8152","authenticated-orcid":false,"given":"Yunhua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology  Guangzhou China"},{"name":"Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02016.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168991"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13789"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12392"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12694"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13688"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.05.022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04550-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15020258"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12081259"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04734-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.08.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.01.033"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.08.045"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00524"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04816"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101825"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202514461"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501254"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303637"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2024.101249"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11414"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501254"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.02.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.09.052"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00121-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.10071"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100491"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00196A"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1757"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102540"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201800500"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01466D"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8100606"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-005-2617-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300315"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3242"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01973-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900903"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11208"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29122823"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0166206"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716164115"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124102"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2024.106858"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4095(20020816)14:16<1120::AID-ADMA1120>3.0.CO;2-9"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0294(02)00008-0"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2009.03.080"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2007.07.007"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0437"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701753213183"},{"key":"e_1_2_8_56_1","first-page":"41","article-title":"Evaluation of Compressive Strength of Several Pulp Capping Materials","volume":"22","author":"Omrani L. R.","year":"2021","journal-title":"Journal of Dentistry"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.08.070"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB00302H"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0312916"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.016"},{"key":"e_1_2_8_61_1","first-page":"257","article-title":"Stimuli\u2010Responsive Hydrogels for Bone Tissue Engineering","volume":"5","author":"Xue C.","year":"2024","journal-title":"Biomaterials Translational"},{"key":"e_1_2_8_62_1","first-page":"236","article-title":"The Use of Hydrogel Microspheres as Cell and Drug Delivery Carriers for Bone, Cartilage, and Soft Tissue Regeneration","volume":"5","author":"Lin C.\u2010H.","year":"2024","journal-title":"Biomaterials Translational"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201300584"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112018"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2013.38"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303709"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.03.008"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1493-5"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad4ada"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.004"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11026-9"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099585"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05203-y"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S141366"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.122.000618"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02467-w"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v041a13"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.06.011"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124173"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.08.035"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406118"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.08.015"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.039"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.7"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0826-2"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.11.005"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:02:11Z","timestamp":1786474931000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":86,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.75497"],"URL":"https:\/\/doi.org\/10.1002\/advs.75497","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"2026-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75497"}}