{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:24:01Z","timestamp":1789496641963,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017FYA0205301"],"award-info":[{"award-number":["2017FYA0205301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1467600"],"award-info":[{"award-number":["22ZR1467600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastrointestinal cancer detection technologies are evolving; capsule endoscopy (CE) overcomes the invasiveness of tethered endoscopes. However, current CEs exhibit limited penetration depth and low SNR due to strong photon scattering, absorption, and autofluorescence in biological tissues, potentially resulting in missed deep or small lesions. This study reports a near\u2010infrared\u2010II fluorescent imaging capsule endoscope (NIR\u2010II FICE), a \u201csmart pill\u201d designed for early gastrointestinal cancer diagnosis. NIR\u2010II FICE can detect NIR\u2010II\u2010specific fluorescence signals above 900\u00a0nm from lesional tissues using the NIR\u2010II fluorescent nanoprobe (FNP). It possesses the advantages of high sensitivity, high resolution, strong tissue penetration ability, high SNR, and high\u2010contrast imaging. Experiments show NIR\u2011II FICE can detect FNP at concentrations as low as 5\u00a0\u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and image large\u2011scale irregular regions and minute areas down to 100\u00a0\u00b5m. In ex vivo experiments on porcine gastric tissue, the penetration depth achieved 4\u00a0mm, with SNRs exceeding 13\u00a0dB and contrast values all greater than 0.5. In vivo experiments enabled targeted imaging of lesions in nude mice. Furthermore, a wireless\u2010powered, magnetically controlled device ensures continuous energy and precise motion for NIR\u2011II FICE. To our knowledge, this is the first CE platform for NIR\u2010II fluorescence imaging, advancing non\u2010invasive gastrointestinal disease diagnosis\/treatment and clinical research.\n                  <\/jats:p>","DOI":"10.1002\/advs.75532","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:48:36Z","timestamp":1778597316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Wireless, Deep\u2010Seeing Smart Pill: A NIR\u2010II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Weicheng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-5711","authenticated-orcid":false,"given":"Zhengting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Global Institute of Future Technology Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-9168","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1630-3924","authenticated-orcid":false,"given":"Qirui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical and Engineering Cross Research Institute the First Affiliated Hospital of Henan University  Kaifeng P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsheng","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai P. R. China"},{"name":"Medical and Engineering Cross Research Institute the First Affiliated Hospital of Henan University  Kaifeng P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(23)00366\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07858J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010015\u20104359\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202001066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11081367"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7424"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013140"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100140\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2005.00274.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010306578"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230X\u201012\u201090"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.04.038"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2018.101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2017.2699973"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.04.21"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2852715"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/s17071553"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics4020057"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105107(05)00323\u20108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.002405"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3052"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.001146"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800205"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.422453"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5830759"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBCAS.2010.2079932"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proeng.2012.09.081"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2013.03.037"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2020.2990293"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18591"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.02.023"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116209"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016924\u2010z"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007040"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010019\u20100494\u20100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2021.3130195"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103098"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201005975\u20107"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM01440J"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4476"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:34:15Z","timestamp":1788867255000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":41,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.75532"],"URL":"https:\/\/doi.org\/10.1002\/advs.75532","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2025-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75532"}}