{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:11:16Z","timestamp":1788869476114,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308400"],"award-info":[{"award-number":["2023YFC2308400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFE0206100"],"award-info":[{"award-number":["2025YFE0206100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42477016"],"award-info":[{"award-number":["42477016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072314"],"award-info":[{"award-number":["82072314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZFJH003"],"award-info":[{"award-number":["2022ZFJH003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multidrug\u2010resistant\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    is a global health threat circulating across humans, animals, food, and environments. Despite increasing One Health surveillance, it remains unclear whether the dominant antimicrobial resistance (AMR) reservoirs in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    are universal or depend on regional ecological context. Here, a synchronized One Health survey in Pingguo, China (5384 samples) is integrated with parallel cross\u2010niche datasets (Italy, Ghana) and a 69184 public genome collection, mapping AMR ecology via network metrics and lineage\u2010aware mixed models. In Pingguo, high\u2010risk determinants are enriched in humans, whereas overall AMR burdens and multidrug resistance platforms are enriched outside humans. Across the public dataset, AMR reservoir dominance varies eco\u2010geographically, with nonhuman isolates carrying higher AMR gene burdens in the China subset (mean +4.5 per isolate), largely due to animal and environmental isolates, while human isolates carry higher burdens in the U.S. and Europe subsets. Lineage explains 44.8% of the burden difference. Remaining within\u2010lineage differences, reservoir\u2010matched integron enrichment, and region\u2010specific connectivity suggest additional horizontal gene transfer\u2010related contributions. This is supported in Pingguo by a highly structured cross\u2010niche plasmid\u2010sharing network shaped by specific plasmid groups and successful lineages. Overall, dominant AMR reservoirs are eco\u2010geographically contingent. Integron load and cross\u2010niche connectivity provide indicators for tiered, region\u2010tailored surveillance.\n                  <\/jats:p>","DOI":"10.1002\/advs.75537","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:46:20Z","timestamp":1778064380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eco\u2010Geography Reverses Dominant AMR Reservoirs in\n                    <i>Klebsiella pneumoniae<\/i>\n                    : Integron\u2010Rich Mobilomes and Cross\u2010Niche Connectivity"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-8069","authenticated-orcid":false,"given":"Hui","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Product Zhejiang Provincial Key Laboratory of Agricultural Microbiomics Institute of Environment Resource, Soil and Fertilizer Zhejiang Academy of Agricultural Sciences  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-4022","authenticated-orcid":false,"given":"Biao","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University  Hangzhou P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Mao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-0687","authenticated-orcid":false,"given":"Wenhong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Zhejiang Chinese Medical University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Zhejiang Chinese Medical University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University  Hangzhou P. R. China"},{"name":"Yuhang Institute of Medical Science Innovation and Transformation  Hangzhou P. R. China"},{"name":"Jinan Microecological Biomedicine Shandong Laboratory  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou P. R. China"},{"name":"Department of Microbiology School of Life Sciences Fudan University  Shanghai P. 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