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However, the upstream regulators that could be targeted for therapeutic intervention remain poorly defined. This study identifies gamma\u2010glutamyl transferase 1 (GGT1) as a key driver of ferroptosis, upregulated in neurons post\u2010SCI. Screening a 150\u2010compound natural product library, we discovered Enocyanin (EA), which reduced GGT1 protein levels, protected neurons from hypoxic injury, and exhibited anti\u2010ferroptotic effects. Mechanistically, EA promoted GGT1 degradation through the E3 ligase MGRN1, leading to K48\u2010linked polyubiquitination and proteasomal clearance, halting ferroptosis. To improve EA's stability and delivery, we engineered a biomimetic nanoplatform (NSCm@EA) using neural stem cell membranes, enhancing drug accumulation at the injured spinal cord. At single\u2010cell resolution, NSCm@EA was shown to precisely remodel neuronal subpopulations, selectively expanding \u03b3\u2010motor neurons and upregulating synaptic genes such as Gria2 and Negr1, while suppressing inflammatory and oxidative stress pathways. In summary, this study reveals GGT1's role in ferroptosis, identifies a natural product that induces its ubiquitin\u2010mediated degradation, and presents a targeted biomimetic delivery strategy for precise intervention in spinal cord injury.<\/jats:p>","DOI":"10.1002\/advs.75554","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:47:26Z","timestamp":1778770046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cMembrane\u2010Guided\u201d Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons"],"prefix":"10.1002","volume":"13","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 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