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Here, we report a lipid\u2010droplet\u2010engineered, gallium\u2010loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co\u2010delivering all\u2010trans retinoic acid (ATRA), termed LDTG A\u2010MNs, for synergistic antibacterial therapy and accelerated wound repair. The engineered LDTG exhibit strong bacteria\u2010targeting capability by mimicking host lipid droplets and efficiently generate reactive oxygen species (ROS) under ultrasound irradiation to achieve potent sonodynamic bactericidal activity. The bilayer MN design enables rapid release of LDTG for targeted bacterial capture, followed by sustained ATRA release to modulate macrophage polarization and promote tissue regeneration. In vitro, LDTG A\u2010MNs demonstrate robust antibacterial and biofilm\u2010disrupting effects, excellent biocompatibility, and enhanced M2\u2010type macrophage polarization. In vivo, LDTG A\u2010MNs combined with ultrasound effectively eradicate bacterial infection, suppress excessive inflammation, improve collagen deposition, enhance angiogenesis, and significantly accelerate wound closure in infected murine skin wounds. This work presents a minimally invasive and infection\u2010responsive MN system that integrates pathogen targeting, sonodynamic antibacterial therapy, and immune\u2010regulated tissue repair, offering a promising therapeutic strategy for the management of complex and refractory infected wounds.<\/jats:p>","DOI":"10.1002\/advs.75589","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:02:49Z","timestamp":1778065369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual\u2010Stage Microneedle Patch With Lipid Droplet\u2010Mediated \u2018Capture\u2010Kill\u2019 and Sustained Release for Enhanced Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Peng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Burns Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University Wuhan P. R. 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