{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:04:04Z","timestamp":1786122244378,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570814"],"award-info":[{"award-number":["82570814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500836"],"award-info":[{"award-number":["82500836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240244"],"award-info":[{"award-number":["BK20240244"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal ischemia\u2010reperfusion (I\/R) injury, a primary cause of acute kidney injury (AKI), is driven by a self\u2010amplifying loop of oxidative burst and immune cell infiltration. In this work, the classical herb pair\n                    <jats:italic>Astragalus membranaceus<\/jats:italic>\n                    (AM) and\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    (AS) is employed as a composite precursor to synthesize nitrogen\u2010rich carbon\u2010dot nanozymes (AM\u2010AS@CDs) via a one\u2010step hydrothermal method. AM\u2011AS@CDs exhibit superoxide dismutase (SOD)\u2010mimetic activity superior to that of CDs derived from single herbs. In vitro, AM\u2010AS@CDs effectively alleviate oxidative stress\u2010induced cellular damage and significantly inhibit apoptosis. In vivo, AM\u2010AS@CDs markedly attenuate I\/R\u2010induced AKI and reduce immune cell infiltration in renal tissues. Transcriptomic analyses reveal that AM\u2010AS@CDs downregulate the expression and phosphorylation of Fosl1 and c\u2010Jun. Consequently, the AP\u20101\u2010chemokine signaling axis is disrupted, which reduces immune cell recruitment. Furthermore, AM\u2010AS@CDs restore redox homeostasis by upregulating antioxidant enzymes such as SOD, glutathione peroxidase 4 (GPX4), and catalase (CAT). They also attenuate the excessive activation of the Nrf2\/HO\u20101 pathway. Overall, this precursor\u2010formulation strategy enables precise modulation of heteroatom doping and surface chemistry in CDs. AM\u2010AS@CDs effectively interrupt the oxidative\u2010inflammatory positive feedback loop through dual mechanisms. These findings provide both theoretical and material foundations for the development of natural product\u2010based nanozymes for I\/R\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.75596","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:50:46Z","timestamp":1778597446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP\u20101\u2010Mediated Inflammation to Attenuate Renal Ischemia\u2010Reperfusion Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Bixiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"},{"name":"Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-7324","authenticated-orcid":false,"given":"Dengyuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-7142","authenticated-orcid":false,"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"},{"name":"Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6339-6355","authenticated-orcid":false,"given":"Xiaozhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010023\u201000784\u2010z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02385\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115207"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000658\u2010w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.12.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.030"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Asn.0000138232.68452.3b"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2025.100627"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102775"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2020.1769656"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2012060633"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3523"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1688207"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2025.151672"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000875\u20105"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409190"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109693"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00457a"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09663"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010022\u201000828\u20102"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004109"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01619"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202004621"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214042"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712469"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.12.107"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101768"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c02419"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30194015"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1557151"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354241311917"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118982"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28135018"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116429"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00462"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201001072\u20103"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.02.011"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.03.012"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035828\u20102"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.169"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.126217"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106342"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6357"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010020\u201000539\u20106"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.05.024"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.07.022"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.02.006"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158010"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.03.005"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00969"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14181443"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.02.023"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.4.1134"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T09:08:56Z","timestamp":1786093736000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":56,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.75596"],"URL":"https:\/\/doi.org\/10.1002\/advs.75596","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75596"}}