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To cope with stress, individuals frequently engage in hedonic behaviors, such as eating palatable food, which provide transient relief from psychological distress and may protect against the development of pathology. However, the neural mechanisms by which hedonic experience counteracts stress\u2010induced anxiety remain poorly understood. Here, we identify a neural circuit functionally connecting the prefrontal cortex (PFC) to the paraventricular nucleus (PVN) of the hypothalamus that mediates stress mitigation through palatable food intake. Activation of this circuit suppresses stress\u2010induced hyperactivity of PVN corticotropin\u2010releasing factor (CRF) neurons and prevents the development of anxiety\u2010like behaviors. This effect is driven by palatable\u2010food\u2010induced dopamine release in the PFC, which activates dopamine D1 receptor (D1R)\u2010expressing neurons projecting to corticotropin\u2010releasing factor receptor 1 (CRFR1)\u2010expressing neurons in the PVN and peri\u2010PVN. Notably, GABAergic CRFR1 neurons are enriched in the peri\u2010PVN, with minimal presence within the PVN proper, suggesting that inhibition of PVN\n                    <jats:sup>CRF<\/jats:sup>\n                    neurons is mediated indirectly via peri\u2010PVN GABAergic inputs. These findings define a previously uncharacterized PFC\u2192peri\u2010PVN\u2192PVN circuit through which hedonic experience modulates stress responses and reveal a neural substrate for behavioral resilience, providing a potential avenue for anxiety intervention.\n                  <\/jats:p>","DOI":"10.1002\/advs.75604","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:31:22Z","timestamp":1778434282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Palatable\u2010Food\u2013Driven Top\u2010Down Circuit Inhibits PVN\n                    <sup>CRF<\/sup>\n                    Activity to Mitigate Stress Via Peri\u2010PVN\n                    <sup>CRFR1<\/sup>\n                    Neurons"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuchuan","family":"Hong","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological 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