{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:47:29Z","timestamp":1785775649271,"version":"3.56.0"},"reference-count":63,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300421131"],"award-info":[{"award-number":["252300421131"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Class Switch Recombination (CSR) is essential for generating high\u2010affinity antibody isotypes from IgM during adaptive humoral responses. Despite well\u2010established roles for various transcription factors, whether CSR is subject to dedicated post\u2010transcriptional control represents a significant gap in knowledge. By integrating conditional knockout models with SLE disease contexts, this study is the first to identify that the RNA\u2010binding protein, poly(A)\u2010specific ribonuclease (PARN), serves as a key positive regulator of antibody\u2010secreting cell function. Mechanistically, PARN preferentially binds 3\u2032 UTRs and enhances the utilization of proximal poly(A) sites on a genome\u2010wide scale in vivo. Further results show that PARN binds UGUA and AA(U\/A)AAA upstream elements to form a specific spatial RNA\u2013protein complex, through which it exerts exonuclease activity to shorten poly(A) tails, thereby decreasing mRNA stability. In addition, we identified a class of functional genes\u2014including\n                    <jats:italic>Foxp1<\/jats:italic>\n                    \u2014whose dynamic 3\u2032 UTR changes directly regulate antibody secretion. This study reports a novel post\u2010transcriptional mechanism by which PARN promotes antibody production through modulation of 3\u2032 UTR length. These findings not only advance our understanding of humoral immune regulation but also highlight a potential therapeutic target for autoimmune diseases such as SLE.\n                  <\/jats:p>","DOI":"10.1002\/advs.75609","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:49:16Z","timestamp":1778597356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The RNA\u2010Binding Protein PARN Remodeled 3\u2032 UTR Structure Defines Poly(A)\u2010Loading Sites to Mediate Immunoglobulin Homeostasis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3638-6724","authenticated-orcid":false,"given":"Siyuan","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Optometry and Vision Science Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naijing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People\u2032s Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Tang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology Beijing Key Laboratory of Pediatric Organ Failure Department of Pediatrics the Seventh Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology Beijing Key Laboratory of Pediatric Organ Failure Department of Pediatrics the Seventh Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchang","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiru","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Nie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazheng","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9792-7995","authenticated-orcid":false,"given":"Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100257\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201005771\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18848"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1395"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)00078\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.10.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae867"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010019\u20100145\u2010z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3813"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010023\u201000980\u2010y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010017\u20100028\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3115"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201037308\u2010z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13580"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010018\u20100076\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.04.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112284"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026908\u20102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119953"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001705200"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010162"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201022\u20103965"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3184"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201809\u20101632LE"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810201"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201001898\u20107"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.39"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151724"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004144\u20104"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114525"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44319\u2010024\u201000152\u20103"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.70015"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.156919.113"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.12.021"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.043893"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201010\u2010462846"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039969\u20107"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1047"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.771132"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.01.010"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201083529\u2010x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.07.037"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.210211.112"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.11.031"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010025\u201003852\u20108"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.116"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.39"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165\u2010008\u20100085\u20105"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.01.004"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102329"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2414"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1845"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.2.208"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407774"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.07.073"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn458"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.139"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111515200"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105139"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005166"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.794834"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.03.001"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.296"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:02:29Z","timestamp":1785772949000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":63,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.75609"],"URL":"https:\/\/doi.org\/10.1002\/advs.75609","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2026-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75609"}}