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Here, leveraging dual\u2010atom coordination engineering as a rational material design strategy, we successfully synthesized a novel dual\u2010atom manganese\u2010based platform featuring a well\u2010defined asymmetric Mn\n                    <jats:sub>2<\/jats:sub>\n                    \u2010N\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    geometry anchored on hierarchical boron nitride (Mn\u2010BN). Notably, this atomic\u2010level engineering achieves T1 relaxivity of 36.27\u00a0mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 3.0 T and 15.86 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 7.0 T, approximately 10\u2010fold higher than those of clinical agents. Combining advanced characterizations with theoretical calculations reveals that adjacent asymmetrically coordinated Mn centers generate cooperative electronic effects that lower water adsorption energy and shorten the Mn\u2013H distance, thereby enhancing water exchange and optimizing dipole\u2013dipole interactions. The Mn\u2010BN exhibits specific magnetic resonance imaging (MRI) T1 signals for accurate tumor boundary visualization, meanwhile preferential hepatocyte uptake through specific transporters creates differential enhancement for sensitive liver metastases detection. This work positions dual\u2010atom coordination engineering as an effective materials design strategy for precise enhancement of MRI properties, providing new opportunities for developing advanced contrast agents with tailored biological interactions and extended imaging windows.\n                  <\/jats:p>","DOI":"10.1002\/advs.75644","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:39:51Z","timestamp":1780040391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetrically Coordinated Dual\u2010Atom Manganese Contrast Agents Enabling High\u2010Efficiency T1 Enhanced MRI for Precise Tumor Visualization"],"prefix":"10.1002","volume":"13","author":[{"given":"Ding","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Peking University Cancer Hospital and Institute  Beijing P. 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