{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:02:34Z","timestamp":1792069354296,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sulfur hexafluoride (SF\n                    <jats:sub>6<\/jats:sub>\n                    ), a chemically inert and stable gas essential to the electric power industry, poses severe environmental risks due to its persistence and high global warming potential. While traditional degradation methods are inefficient, photocatalytic single electron reduction (SER) enables SF\n                    <jats:sub>6<\/jats:sub>\n                    activation into SF\n                    <jats:sub>5<\/jats:sub>\n                    radicals, creating opportunities for both degradation and reutilization. The SF\n                    <jats:sub>5<\/jats:sub>\n                    group, renowned for its strong electron\u2010withdrawing, lipophilic, and bioisosteric features, has great potential in drug discovery, while efficient methods for synthesizing alkyl\u2010 or BCP\u2010SF\n                    <jats:sub>5<\/jats:sub>\n                    motifs remain scarce. As a safe, inexpensive, and atom\u2010economical alternative to conventional SF\n                    <jats:sub>5<\/jats:sub>\n                    reagents, SF\n                    <jats:sub>6<\/jats:sub>\n                    serves as an ideal yet underexplored SF\n                    <jats:sub>5<\/jats:sub>\n                    source. Herein, we present a photocatalytic strategy for the direct synthesis of diverse SF\n                    <jats:sub>5<\/jats:sub>\n                    \u2010containing scaffolds, including ketones, acetals, and bicyclo[1.1.1]pentane derivatives. Derivatization studies demonstrate its synthetic versatility, particularly in accessing \u03b1\u2010SF\n                    <jats:sub>5<\/jats:sub>\n                    \u2010substituted acetaldehydes. Mechanistic and density functional theory (DFT) studies confirm the single electron reduction of SF\n                    <jats:sub>6<\/jats:sub>\n                    , highlighting a mild, efficient, and broadly applicable route for constructing SF\n                    <jats:sub>5<\/jats:sub>\n                    \u2010functionalized architectures in fluorinated drug development.\n                  <\/jats:p>","DOI":"10.1002\/advs.75663","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:03:17Z","timestamp":1778857397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF\n                    <sub>6<\/sub>"],"prefix":"10.1002","volume":"13","author":[{"given":"Chen\u2010Hui","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei China"},{"name":"Department of Chemistry University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Division of Life Sciences and Medicine The First Affiliated Hospital of USTC 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