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Persistent oxidative stress and inflammation further inhibit osteogenesis and angiogenesis, accelerating bone degeneration. In this study, we used a peptide\u2010polyphenol conjugation strategy to develop a multifunctional colloidal nanoplatform (\u03b2\u2010GP@EGCG\u2010E7). The bone\u2010targeting peptide E7 was covalently conjugated with epigallocatechin\u20103\u2010 gallate (EGCG) and subsequently loaded with \u03b2\u2010glycerophosphate (\u03b2\u2010GP). Sequentially, this nanoplatform integrates bone\u2010targeted delivery, improving mitochondrial quality by anti\u2010inflammation and antioxidation, as well as osteogenesis and angiogenesis within a single system. In detail, in a high glucose microenvironment, the nanoplatform selectively accumulates in bone lesions, scavenges excess intracellular reactive oxygen species (ROS) triggered by high glucose, clears damaged mitochondria by activating PINK1\u2010Parkin mediated mitophagy, and exerts anti\u2010inflammatory effects to rebalance the microenvironment of bone regeneration. Concurrently, sustained phosphate release supports mineralization, promotes osteogenic differentiation, enhances angiogenesis, and improves local microcirculation. In diabetic osteoporotic models, \u03b2\u2010GP@EGCG\u2010E7 significantly reduced oxidative stress, restored mitochondrial homeostasis, and promoted bone and vascular regeneration. This study provides a promising therapeutic strategy for DOP and highlights the potential of peptide\u2010polyphenol hybrid nanomaterials for regenerative applications.<\/jats:p>","DOI":"10.1002\/advs.75666","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:45:31Z","timestamp":1778597131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orchestrated Engineered Polyphenol\u2010Peptide Condensates Coupled With \u03b2\u2010GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiuyun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Peking University School of Stomatology  Beijing China"},{"name":"National Center of Stomatology National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key 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