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Label\u2010free multiphoton microscopy (MPM) reveals tumor\u2010associated collagen signatures (TACS) at the margin, offering a prognostically relevant diagnostic information. However, limited familiarity of novel MPM images by pathologists has prevented its integration into diagnostic workflows. Here, we introduce MarginPath, a Margin Pathological diagnosis system built on an MPM\u2010language model that requires only a single label\u2010free section. By integrating MPM\u2010derived TACS with virtual H&amp;E diagnostic information, MarginPath provides a multimodal diagnostic report, including: (i) a MPM image and corresponding virtual H&amp;E image, (ii) a TACS\u2010based pixel\u2010level margin\u2010status heatmap, and (iii) detailed natural\u2010language diagnostic descriptions of tumor margin microenvironment. 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