{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:29:55Z","timestamp":1786634995213,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574360 82304438"],"award-info":[{"award-number":["82574360 82304438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prevalence of diabetes mellitus (DM) and tuberculosis (TB) comorbidity is constantly rising worldwide, thus there is an urgent need for a co\u2010diagnostic method of TB\u2010DM in the clinic. Here, we introduced a bilateral surface\u2010enhanced Raman scattering (SERS)\u2010microneedle (MN) patch that incorporated Au hybrid mesoporous polydopamine\u2010coated urchin Au\/Ag (U@mP@Au) for analyzing glucose in interstitial fluid (ISF) and TB biomarker (ESAT\u20106\/CFP\u201010) in sputum toward the co\u2010detection of TB\u2010DM comorbidity. The feasibility of the bilateral SERS\u2010MN patch was demonstrated in ex vivo artificial skin, in vivo mouse models, and trials of recruiting patients. In the clinical assessment, DM patients (\n                    <jats:italic>N = 18<\/jats:italic>\n                    ) and healthy subjects (\n                    <jats:italic>N = 3<\/jats:italic>\n                    ) were classified with satisfactory sensitivity (88.9%) and specificity (100%), among which one DM positive sample (P11) with TB infection was successfully identified. Results revealed the sensitivity (87.5%) and specificity (90.9%) of SERS\u2010MN array for TB diagnosis\n                    <jats:italic>(N = 33<\/jats:italic>\n                    ), which were comparable to traditional clinical methods (smear, TST, and Xpert). More importantly, three TB\u2010positive patients (P9, P15, and P20) showed abnormally elevated glucose levels, which is highly suggestive of TB\u2010DM complication. This integrated dual\u2010analyte detecting platform represented a significant step toward the cooperative diagnosis of TB\u2010DM comorbidity, facilitating the early detection of complications by clinicians.\n                  <\/jats:p>","DOI":"10.1002\/advs.75722","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:36:43Z","timestamp":1779694603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral SERS\u2010Microneedle Patch for Co\u2010Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity"],"prefix":"10.1002","volume":"13","author":[{"given":"Xueqin","family":"Huang","sequence":"first","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University  Dongguan China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yu","sequence":"additional","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanze","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaihong","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguang","family":"Cong","sequence":"additional","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-6731","authenticated-orcid":false,"given":"Pinghua","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"},{"name":"Institute for Safflower Industry Research Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of Education School of Pharmacy Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-1248","authenticated-orcid":false,"given":"Jiang","family":"Pi","sequence":"additional","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-0729","authenticated-orcid":false,"given":"Lang","family":"Rao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jierong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-6284","authenticated-orcid":false,"given":"Junxia","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-5968","authenticated-orcid":false,"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University  Dongguan China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University  Guangzhou China"},{"name":"Institute for Safflower Industry Research Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of Education School of Pharmacy Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02479-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.675"},{"key":"e_1_2_9_4_1","first-page":"617","article-title":"The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: a Multicenter Prospective Cohort Study","volume":"225","author":"Arriaga M. B.","year":"2022","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00922-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00087-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04420"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c00444"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.2c02635"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114234"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300321"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c02330"},{"key":"e_1_2_9_13_1","first-page":"14146","article-title":"Microneedle\u2010Coupled Epidermal Sensors for In\u2010Situ\u2010Multiplexed Ion Detection in Interstitial Fluids","volume":"15","author":"Zhu D. D.","year":"2023","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.102012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202300464"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11238"},{"key":"e_1_2_9_17_1","article-title":"Dual\u2010Enhanced SERS Satellite Immuno\u2010Nanocomplex for Multiple PSA\u2010Mediated PHI Assay toward Clinical Prostate Cancer Screening","volume":"12","author":"Chen D.","year":"2025","journal-title":"Advancement of Science"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c04920"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.08.024"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115079"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02070"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c01003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05638"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147528"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101152"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c10817"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac4027669"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.08.068"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13030354"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11092446"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.10.054"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2017.09.007"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma17020509"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01631"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.09.030"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c06261"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101085"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:40:21Z","timestamp":1786632021000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":36,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.75722"],"URL":"https:\/\/doi.org\/10.1002\/advs.75722","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75722"}}