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Here, we developed mastication\u2010driven magnesium\u2010incorporated piezoelectric nanofibers (MagPie) that could convert joint loading into localized electrical stimulation while releasing Mg\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    to neutralize the acidic microenvironment. Under mechanical stimulation, MagPie promoted chondrocyte anabolism and suppressed inflammation in vitro. In a rat temporomandibular joint OA model induced by overloading, MagPie, coupled with physiological mastication, restored the damaged osteochondral unit. Through single\u2010cell transcriptomics, an electro\u2010sensitive Prg4\n                    <jats:sup>+<\/jats:sup>\n                    chondroprogenitor\u2010like cell population was identified as a key mediator of cartilage regeneration. Mechanistically, MagPie\u2010activated Prg4\n                    <jats:sup>+<\/jats:sup>\n                    cells enhanced anabolic activity via the ECM\u2010mediated FAK\u2010PI3K\u2010Akt axis and ameliorated the arthritic microenvironment by shifting macrophage polarization toward an anti\u2010inflammatory phenotype. Genetic ablation of\n                    <jats:italic>Prg4<\/jats:italic>\n                    attenuated the therapeutic efficacy of MagPie. Together, these findings uncover a mechanism of electrosensitive tissue repair and establish a \u2018trash\u2010to\u2010treasure\u2019 strategy that harnesses joint overloading to activate endogenous regenerative programs for OA therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.75725","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:21:33Z","timestamp":1779200493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mastication\u2010Induced Electrical Stimulation Activates Prg4\n                    <sup>+<\/sup>\n                    Chondroprogenitors for Osteoarthritis Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Shi\u2010Yang","family":"Feng","sequence":"first","affiliation":[{"name":"Center For TMD and Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"},{"name":"Beijing Key Laboratory of Biomaterials for Oral Disease Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Rong","family":"Cheng","sequence":"additional","affiliation":[{"name":"NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and 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