{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:38:52Z","timestamp":1791376732626,"version":"4.3.2"},"reference-count":64,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Compact, cost\u2010effective tabletop magnetic resonance elastography (ttMRE) is an emerging research tool for assessing bulk soft tissue biomechanics but still lacks spatially resolved imaging of viscoelastic properties in heterogeneous specimens like tumors. Here, we develop and validate ttMRE for quantifying intratumoral biomechanical heterogeneity in human colorectal liver metastasis (CRLM). We excite cylindrical, multifrequency shear waves and reconstruct viscoelastic maps using adaptive bandpass filters constrained by rheological Bessel\u2010fit priors. In this way, we obtain biophysical markers that agree with ground\u2010truth measurements in numerical and viscoelastic phantoms. In CRLM, shear\u2010wave\u2010speed and penetration\u2010rate maps \u2013 proxies of stiffness and attenuation, respectively \u2013 as well as their derived interquartile range and Shannon entropy, suggest markedly less viscous, stiffer, and more biomechanical heterogeneous tissue in specimens from responders to chemotherapy versus non\u2010responders, with heterogeneity metrics outperforming direct viscoelastic parameters in diagnostic accuracy. These findings establish compact, automated ttMRE as a low\u2010cost, scalable platform for spatial biomechanical profiling and quantitative assessment of treatment response in bulky colorectal liver metastasis specimens.<\/jats:p>","DOI":"10.1002\/advs.75728","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:12:12Z","timestamp":1779203532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9490-9613","authenticated-orcid":false,"given":"Weijie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa\u2010Marie","family":"Skrip","sequence":"additional","affiliation":[{"name":"Department of Surgery Experimental Surgery, CCM|CVK Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Tzsch\u00e4tzsch","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein S.","family":"Aghamiry","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-0688","authenticated-orcid":false,"given":"Alexander","family":"Arnold","sequence":"additional","affiliation":[{"name":"Institute of Pathology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene \u00c4nne","family":"B\u00f6hne","sequence":"additional","affiliation":[{"name":"Institute of Pathology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes K.","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Surgery Experimental Surgery, CCM|CVK Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"G\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Schattenfroh","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanglei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Augusto Dantas","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Department of Surgery Experimental Surgery, CCM|CVK Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-937X","authenticated-orcid":false,"given":"Igor M.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Surgery Experimental Surgery, CCM|CVK Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-1444","authenticated-orcid":false,"given":"Ingolf","family":"Sack","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl H.","family":"Hillebrandt","sequence":"additional","affiliation":[{"name":"Department of Surgery Experimental Surgery, CCM|CVK Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"BIH Charit\u00e9 Digital Clinician Scientist Program Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin BIH Biomedical Innovation Academy  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053374\u20103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz0868"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41567\u2010022\u201001755\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303523"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42254\u2010022\u201000543\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000971"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021219008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.701336"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201019\u20102150"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-025-12002-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/56\/19\/014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24495"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM02264J"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.605205"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103640"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.696304"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212999"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213884"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005559\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2024.106711"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29066"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2024.106746"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26659"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2016.01.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/0305\u20104470\/28\/23\/012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3454738"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000862"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2021.11.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555216682725"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/047174882X"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.52601\/bpr.2025.240049"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12627"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.166"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102612\u20102"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.240138"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216583"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23184"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010024\u201012027\u2010w"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00051"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824057e7"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000001231"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010020\u201008284\u20101"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010024\u201015196\u2010x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2021.101578"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201006706\u2010y"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31883"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1299\/mej.14\u201000417"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2024.05.002"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1190\/1.1443979"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1071\/EG984265a"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1190\/geo2021\u20100606.1"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1190\/geo2018\u20100093.1"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2023.3324922"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1190\/1.1451454"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02032.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.038"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl386"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.14.002692"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361\u20108415(03)00038\u20100"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1090\/S0025\u20105718\u201099\u201001033\u20109"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28247"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1137\/S0036144596301390"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:40:06Z","timestamp":1786632006000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":64,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.75728"],"URL":"https:\/\/doi.org\/10.1002\/advs.75728","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2025-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75728"}}