{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:09:44Z","timestamp":1790867384698,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2419300"],"award-info":[{"award-number":["2024YFC2419300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371942\/82202127\/62131009"],"award-info":[{"award-number":["82371942\/82202127\/62131009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Distinguishing pancreatic ductal adenocarcinoma (PDAC) from mass\u2010forming pancreatitis (MFP) is challenging due to imaging mimicry and reader\u2010dependent variability. PancDS is developed as a biomimetic pancreatic decision\u2010support system that integrates clinical predictors, a radiomics signature, and self\u2010developed deep features (PANet). PancDS is enabled by TriFusionNet, an adaptive fusion strategy designed to emulate expert reasoning by dynamically reweighting modalities according to diagnostic relevance. In a retrospective multicenter cohort of 1006 consecutive patients with pathologically confirmed resectable PDAC or MFP (2014\u20132023), 634 patients from Tongji Hospital were used for training\/internal testing, and 372 patients from four independent hospitals for external testing. PancDS achieves internal and external AUCs of 0.936 (95% CI: 0.864\u20130.993) and 0.881 (95% CI: 0.833\u20130.924), respectively. In a reader study, PancDS significantly improves diagnostic accuracy and sensitivity, with the largest gains in intermediate and junior radiologists (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and minimal case\u2010level deterioration (1.5\u20133.9%), functioning as a diagnostic equalizer. In a prospective consecutive cohort (Jan\u2013Oct 2025; n = 151), PancDS achieves an AUC of 0.869 (95% CI: 0.725\u20130.978) and 94.7% accuracy. This practice\u2010tested, prospectively evaluated system provides a reliable tool for PDAC\u2013MFP differentiation, potentially informing surgical decision\u2010making and enhancing diagnostic equity across diverse clinical environments.\n                  <\/jats:p>","DOI":"10.1002\/advs.75747","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:10:53Z","timestamp":1779214253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PancDS in Real\u2010World Practice: A Prospective Multicenter Validation of a Clinical Decision\u2010Support System Bridging Experience Gaps in Pancreatic Lesion Diagnosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhibo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"College of Life Science and Technology Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinuo","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanxi Bethune Hospital Tongji Shanxi Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji 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