{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:36:28Z","timestamp":1786988188620,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272010"],"award-info":[{"award-number":["82272010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The efficacy of senolytic vaccines aiming to clear senescent cells is limited by narrow antigen coverage and inefficient CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell priming due to poor lymph node (LN) accumulation and inefficient antigen cross\u2010presentation. Here, we report SenoVac, a modular dual\u2010component nanovaccine platform explicitly consisting of two sequentially administered key components: an \u201calbumin hitchhiking\u201d DSPE\u2010PEG\u2010DBCO conjugate, and azide\u2010functionalized senescent cell\u2010derived artificial vesicles (SCAVs) that co\u2010encapsulate the sonosensitizer hematoporphyrin monomethyl ether (HMME) and the TLR7\/8 agonist adjuvant resiquimod (R848). The first administered DSPE\u2010PEG\u2010DBCO conjugate leverages endogenous albumin transport to traffic efficiently to LNs, where it installs bioorthogonal DBCO docking sites; the subsequent administration of SenoVac's azide\u2010functionalized SCAVs facilitates specific and sustained accumulation in LNs via click chemistry. In the LNs, local therapeutic ultrasound irradiation activates HMME to generate reactive oxygen species (ROS), which disrupt dendritic cell endosomal membranes, promoting senescence\u2010associated antigens (SAAs) escape into the cytoplasm and robust cross\u2010presentation to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. In an ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse model of atherosclerosis, this integrated platform effectively cleared plaque senescent cells, attenuated disease progression, and showed a favorable safety profile. Our work establishes a translatable strategy that combines active LN targeting with stimulus\u2010responsive cross\u2010presentation enhancement for senolytic immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.75770","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:07:37Z","timestamp":1779282457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Senescent Cell Derived Artificial Vesicle\u2010Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross\u2010Presentation Efficacy"],"prefix":"10.1002","volume":"13","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi 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Management of Gastrointestinal Cancers Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-2564","authenticated-orcid":false,"given":"Lijun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi 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