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However, current platforms lack the ability to integrate quantitative molecular imaging with spatially confined immune modulation. Here, we report a nanotheranostic platform Pt\n                    <jats:sub>2<\/jats:sub>\n                    Te\n                    <jats:sub>3<\/jats:sub>\n                    :Ag\n                    <jats:sub>2<\/jats:sub>\n                    Te\u2010\u03b1PD\u2010L1 (PAPD) based on bandgap\u2010engineered Pt\n                    <jats:sub>x<\/jats:sub>\n                    Te\n                    <jats:sub>y<\/jats:sub>\n                    :Ag\n                    <jats:sub>2<\/jats:sub>\n                    Te quantum dots. Platinum\u2010induced electronic reconfiguration enables programmable bandgap modulation, yielding tunable near\u2010infrared IIb emission spanning from 1550 to 2200 nm. Pt\n                    <jats:sub>2<\/jats:sub>\n                    Te\n                    <jats:sub>3<\/jats:sub>\n                    :Ag\n                    <jats:sub>2<\/jats:sub>\n                    Te quantum dots exhibit stable emission at 1730 nm and controllable mild photothermal effects. Conjugation with \u03b1PD\u2010L1 antibodies endows the PAPD platform with dual tumor\u2010targeting capability through EPR\u2010mediated passive accumulation and PD\u2010L1\u2010specific active recognition. Crucially, near\u2010infrared IIb molecular imaging enables quantitative monitoring of tumor targeting and therapeutic response, meanwhile mild photothermal modulation induces immune reprogramming that sensitizes tumors to immune checkpoint immunotherapy in vivo. This work establishes a generalizable quantum\u2010engineered nanotheranostic platform, offering a scalable strategy for precision cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.75777","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:15:44Z","timestamp":1779290144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bandgap\u2010Engineered Pt\n                    <sub>x<\/sub>\n                    Te\n                    <sub>y<\/sub>\n                    :Ag\n                    <sub>2<\/sub>\n                    Te Composite Quantum Dots Enable Programmable NIR\u2010II Imaging and Photothermal\u2010Immune Synergistic Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences  Hangzhou 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