{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:18:33Z","timestamp":1790036313609,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Real\u2010time, non\u2010destructive monitoring of electrophysiological dynamics of 3D organoids is imperative for advancing disease modeling and high\u2010throughput drug screening. However, obtaining continuous, reliable signals remains difficult due to the destructive nature of penetrating probes and the unreliable contact issue prone to surface recordings. Here, we present a stretchable 3D microelectrode array with microneedles (3D MN\u2010sMEA) fabricated via a scalable wafer\u2010level stud\u2010bump bonding process for minimally destructive and stable monitoring. We achieve high\u2010fidelity, reliable electrophysiological recordings of both human iPSC\u2010derived heart and cerebral models. Compared with 2D and 3D planar microelectrodes, 3D microelectrodes with microneedles achieve a higher signal\u2010to\u2010noise ratio and greater long\u2010term recording stability. Furthermore, quantitative pharmacological profiling validates its ability to enable precise drug screening. By combining scalable manufacturing with flexible, tissue\u2010compliant interfaces, our approach enables stable, minimally invasive, and long\u2010term electrophysiological monitoring of 3D organoids for scalable disease modeling and drug discovery.<\/jats:p>","DOI":"10.1002\/advs.75778","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:50:48Z","timestamp":1779288648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids"],"prefix":"10.1002","volume":"13","author":[{"given":"Eunyoung","family":"Jang","sequence":"first","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saewoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biophysics Sungkyunkwan University  Gyeonggi\u2010do Republic of Korea"},{"name":"Institute of Quantum Biophysics Sungkyunkwan University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul\u2010Gi","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiup","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoojeong","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-6749","authenticated-orcid":false,"given":"Il\u2010Joo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine College of Medicine Korea University  Seoul Republic of Korea"},{"name":"Department of Anatomy &amp; Brain Korea 21 Plus Program for Biomedical Science College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Gogos","sequence":"additional","affiliation":[{"name":"Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University  New York New York USA"},{"name":"Stavros Niarchos Foundation Center for Precision Psychiatry and Mental Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biophysics Sungkyunkwan University  Gyeonggi\u2010do Republic of Korea"},{"name":"Institute of Quantum Biophysics Sungkyunkwan University  Gyeonggi\u2010do Republic of Korea"},{"name":"Department of Biopharmaceutical Convergence Sungkyunkwan University  Suwon Republic of Korea"},{"name":"Department of Metabiohealth Sungkyunkwan University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u2010Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo J.","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"},{"name":"KAIST Institute for NanoCentury (KINC)  Daejeon Republic of Korea"},{"name":"Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of 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