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We prepared a novel\n                    <jats:italic>Herba Lysimachiae<\/jats:italic>\n                    polysaccharide\u2010modified selenium nanoparticle (HLP\u2010SeNPs) formulation that enhances the stability and antioxidant activity of selenium nanoparticles (SeNPs) to alleviate oxalate\u2010induced renal injury. In vivo and in vitro studies showed that HLP\u2010SeNPs possess pronounced anti\u2010oxidative stress capacity, restore mitochondrial membrane potential, alleviate mitochondrial damage, reduce RTEC death, and inhibit renal calcium oxalate (CaOx) crystal deposition. Mechanistically, HLP\u2010SeNPs downregulate TOMM22 (translocase of the outer mitochondrial membrane 22, a core TOM complex subunit) to activate PINK1\u2010Parkin\u2010mediated mitophagy, thereby effectively limiting oxidative stress\u2010induced injury at its source. These findings indicate that HLP\u2010SeNPs exert substantial renoprotective effects and prevent CaOx stone formation, providing an experimental foundation for mitochondria\u2010targeted nanotherapeutics in kidney stone disease and highlighting the potential of integrating traditional Chinese medicine with nanomaterials.\n                  <\/jats:p>","DOI":"10.1002\/advs.75784","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:15:42Z","timestamp":1779203742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Herba Lysimachiae<\/i>\n                    Polysaccharide\u2010Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22\u2010Regulated Mitophagy Activation"],"prefix":"10.1002","volume":"13","author":[{"given":"Junyi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology, Institute of Urology, Tongji Hospital, 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