{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:21Z","timestamp":1787596101628,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172681"],"award-info":[{"award-number":["82172681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470690"],"award-info":[{"award-number":["82470690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with advanced hepatocellular carcinoma (HCC) have a poor prognosis and few effective treatments. The highly immunosuppressive tumor microenvironment and multifaceted immune escape mechanisms in HCC profoundly restrict the clinical efficacy of immune checkpoint inhibitors. Phosphoglycerate kinase 1 (PGK1) is established as an oncogenic driver in malignant tumor progression. However, its role in modulating tumor immunity remains elusive. This study found that HCC cell\u2010intrinsic PGK1 contributed to tumor progression through inhibiting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated antitumor immunity. Then, in vivo and in vitro results demonstrated that tumor\u2010associated macrophages (TAMs) function as critical mediators in PGK1\u2010driven immunosuppression. Furthermore, PGK1 promoted the recruitment and M2 polarization of TAMs through upregulation of C\u2010C motif chemokine ligand 2 (CCL2)\u00a0expression. Blockade of CCL2 significantly attenuated PGK1\u2010induced infiltration of C\u2010C motif chemokine receptor 2 (CCR2)\n                    <jats:sup>+<\/jats:sup>\n                    TAMs and inhibited M2 polarization, while reversing the impaired infiltration and function of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. This work further demonstrated that PGK1 enhanced CCL2 secretion through activating the AKT\/GSK3\u03b2\/\u03b2\u2010catenin pathway in HCC cells. In vivo experiments revealed that the combination of PGK1 inhibitor and immunotherapy\u00a0elicited potent antitumor efficacy. Taken together, this study highlighted PGK1 as a pivotal regulator of tumor immunobiology and provided novel insights into combination immunotherapy for HCC.\n                  <\/jats:p>","DOI":"10.1002\/advs.75801","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:44:38Z","timestamp":1779720278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PGK1 Suppresses CD8\n                    <sup>+<\/sup>\n                    T Cell\u2010Mediated Antitumor Immunity Through CCL2\/CCR2\/Tumor\u2010Associated Macrophages Axis in Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Xi","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"NHC Key Laboratory of Combined Multi\u2010Organ 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