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This process is regulated by specific metabolites, the lipid composition of the cells, redox\u2010active iron, and antioxidant mechanisms. Although numerous regulators have been identified over the past decade, exploring other mechanisms, particularly from non\u2010coding genomic regions, can build a thorough understanding of the multifaceted regulatory processes underlying ferroptosis. MicroRNAs (miRNAs) play a crucial role in gene regulation and cellular functions. Through a CRISPR KO screen, we identified miR\u2010940 as a negative regulator of ferroptosis. Overexpression of miR\u2010940 in several cell lines consistently suppressed ferroptosis induced by system x\n                    <jats:sub>c<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    inhibition. Notably, multiple cancer patient cohorts with elevated miR\u2010940 levels exhibit reduced survival. Integrated bioinformatic, transcriptomic, and proteomic analyses revealed that miR\u2010940 decreases the expression of ACSL4, LPCAT3, DMT1, and NCOA4, and simultaneously increases levels of GPX4. Pharmacological inhibition of GPX4 attenuated the protective effect of miR\u2010940, indicating that its primary anti\u2010ferroptotic activity is mediated through GPX4. Overall, these mechanistic insights link gene rewiring to reduced levels of redox\u2010active iron and diminished lipid peroxidation, mediating ferroptosis suppression. These findings provide a defined regulatory network, presenting a novel target for therapeutic exploration in susceptible cancers.\n                  <\/jats:p>","DOI":"10.1002\/advs.75830","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:17:43Z","timestamp":1780064263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MiR\u2010940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes"],"prefix":"10.1002","volume":"13","author":[{"given":"Andrea","family":"Kolak","sequence":"first","affiliation":[{"name":"Cell Signaling and Chemical Biology, Research Unit Signaling and Translation Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Tschuck","sequence":"additional","affiliation":[{"name":"Cell Signaling and Chemical Biology, Research Unit Signaling and Translation Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A. 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