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Single\u2010atom nanozymes (SANs), with their well\u2010defined structures and maximal atomic efficiency, show great potential for treating ROS\u2010induced diseases by mimicking natural enzymes. However, the strong binding between transition metal sites and electron\u2010donating intermediates (e.g., O*, OH*, OOH*) creates high energy barriers, limiting their catalytic activities. Herein, single\u2010atomic platinum is successfully embedded into CeO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    to form CeO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    \/Pt SANI, which enhanced catalytic activity via an \u201cisland\u2010sea\u201d synergistic effect. Leveraging the unique charge\u2010transfer structures and confinement effect of nanoislands, CeO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    \/Pt SANI exhibits superior enzymatic activities than CeO\n                    <jats:sub>2<\/jats:sub>\n                    , attribute to the island\u2010sea synergistic effect that facilitates strong electron transfer, as proved by density functional theory (DFT) calculations. DFT calculations further demonstrate that Pt incorporation increases oxygen vacancies and tunes the d\u2010band center toward the Fermi level, facilitating ROS adsorption and accelerating redox reactions. Single\u2010cell sequencing and experimental results confirm that CeO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    \/Pt SANI reprograms the oxidative microenvironment, leading to significant therapeutic effects in SONFH. This study provides insights into the rational design of an advanced \u201cisland\u2010sea\u201d structured single\u2010atom nanozyme to optimize the catalytic activity.\n                  <\/jats:p>","DOI":"10.1002\/advs.75840","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:26:12Z","timestamp":1779805572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oxygen Vacancy\u2010Enriched Platinum Single\u2010Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-9130","authenticated-orcid":false,"given":"Yang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neurosurgery Research Institute The First Affiliated Hospital Fujian Medical University  Fuzhou Fujian 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