{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:18Z","timestamp":1787596098376,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH265"],"award-info":[{"award-number":["ZR2024MH265"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunotherapy has emerged as a promising therapeutic option for cancer management, but its applicability in patients with triple\u2013negative breast cancer (TNBC) is limited by the low efficacy due to the immunosuppressive tumor microenvironment (TME). Here, we identify lysine demethylase 3B (KDM3B) as an essential mediator of immune evasion in TNBC. KDM3B expression is negatively correlated with cytotoxic T lymphocyte (CTL) infiltration. Genetic or pharmacologic inhibition of KDM3B facilitates the recruitment and activation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, thereby suppressing tumor growth in TNBC mouse models. Mechanistically, KDM3B targets SHP1 by reducing H3K9me2 levels at its promoter. Suppression of KDM3B attenuates SHP1\u2013mediated STING inactivation, which triggers robust type I interferon (IFN) responses. Strikingly, both KDM3B depletion and treatment with the KDM3B\u2013selective inhibitor P3FI\u201390 significantly suppresses tumor progression and mitigates resistance to immune checkpoint blockade (ICB) therapy. Taken together, these findings establish KDM3B as a key regulator of immune escape, and targeting KDM3B represents a promising strategy to augment the efficacy of immunotherapy for TNBC.\n                  <\/jats:p>","DOI":"10.1002\/advs.75846","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:11:03Z","timestamp":1779894663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting KDM3B Elicits Anti\u2010tumor Immunity by Alleviating SHP1\u2013mediated STING Suppression in Triple\u2013Negative Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaolong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Biological Resource Center Qilu Hospital of Shandong University  Jinan Shandong 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China"},{"name":"Biological Resource Center Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Research Institute of Breast Cancer Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001389"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188593"},{"key":"e_1_2_12_5_1","first-page":"987","article-title":"Atezolizumab and Nab\u2013Paclitaxel in Advanced Triple\u2013Negative Breast Cancer","volume":"380","author":"Schmid P.","year":"2019","journal-title":"Reply The New England Journal of 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