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Senescent cell accumulation\u2014driven by continuous generation and apoptotic resistance\u2014perpetuates plaque pathology and obstructs regression. This study addresses the reversal conundrum through a dual\u2010action strategy: blocking new senescent cell formation while enhancing clearance of existing senescent cells. We developed a ROS\u2010responsive dimeric prodrug (K\n                    <jats:sub>2<\/jats:sub>\n                    A) from the MPO\u2010inhibitory tripeptide KYC, which co\u2010assembles with the senolytics Navitoclax into a nano\u2010Senotherapy (N@K\n                    <jats:sub>2<\/jats:sub>\n                    A). Further cloaked with neutrophil membranes from AS mice, the biomimetic N@K\n                    <jats:sub>2<\/jats:sub>\n                    A@NEM precisely targets plaques, responds to local ROS, and orchestrates senescent cell formation and removal. This targeted senotherapeutic intervention demonstrates effective reversal of established experimental AS, offering a potential solution to the field's most pressing clinical dilemma.\n                  <\/jats:p>","DOI":"10.1002\/advs.75850","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:49:52Z","timestamp":1779720592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathological Mechanism\u2010Inspired Biomimetic Nano\u2010Senotherapy for Reversing Experimental Atherosclerosis in ApoE\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuhan","family":"Tian","sequence":"first","affiliation":[{"name":"College of Pharmacy and Food Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai\u2010Tibet Plateau Southwest Minzu University  Chengdu 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