{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:16Z","timestamp":1787596096462,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The cGAS\u2010STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic potential is often limited by the inefficient cytosolic delivery of agonists and the immunosuppressive tumor microenvironment (TME). Here, we report a DNA nanostructure\u2010based platform that simultaneously induces lysosomal degradation of immune checkpoint protein PD\u2010L1 and activates the STING pathway. We demonstrate that STING activation further enhances PD\u2010L1 degradation, resulting in strong synergistic immune activation. In murine models of triple\u2010negative breast cancer, the DNA nanodevice effectively reprograms the TME by enhancing dendritic cell maturation and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, resulting in potent suppression of both primary tumor growth and pulmonary metastases. This study establishes a versatile nanoplatform that bridges targeted protein degradation with STING\u2010mediated innate immune activation, provides a promise strategy for cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.75855","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:08:14Z","timestamp":1779894494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome\u2010Targeted PD\u2010L1 Degradation"],"prefix":"10.1002","volume":"13","author":[{"given":"Haoxiang","family":"Li","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Physics and Chemistry Hunan First Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1594-4023","authenticated-orcid":false,"given":"Jian\u2010Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-2662","authenticated-orcid":false,"given":"Jianjun","family":"He","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha China"},{"name":"FuRong Laboratory  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010019\u20100203\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100116\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0705-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba6098"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013094\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.09.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8172"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"An Inflammation\u2010Targeting Hydrogel for Local Drug Delivery in Inflammatory Bowel Disease","volume":"7","author":"Juan Fu D. 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