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Here, genomic analysis demonstrated that B16F10 tumor cells subjected to in vitro irradiation faithfully recapitulate part of the radiotherapy\u2010induced mutational landscape observed in subcutaneous tumor models. Based on these findings, a biomimetic cancer vaccine was developed through the integration of RT\u2010treated tumor cell membranes and manganese\u2010based metal organic framework nanoadjuvants (Mn@RM). Mn@RM can deliver RT\u2010induced membrane proteins directly to lymph nodes in order to potentiate the in situ vaccine immune response. Moreover, Mn\u2010MOF nanoadjuvants enhanced antigen presentation efficiency by nearly two\u2010fold through activation of the cGAS\u2010STING pathway in dendritic cells, while Mn@RM further optimized the lymph node immune microenvironment to promote robust anti\u2010tumor immunity. When combined with radiotherapy and PD\u20101 immune checkpoint blockade, Mn@RM demonstrates excellent synergistic tumor treatment effect. Overall, this study offers a promising and clinically translatable platform to augment radiotherapy induced anti\u2010tumor immunity, particularly for patients receiving radiotherapy in conjunction with surgical interventions.<\/jats:p>","DOI":"10.1002\/advs.75860","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:12:38Z","timestamp":1780063958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining Radiation\u2010Treated Tumor Vaccines With Mn\u2010MOF Nanoadjuvants to Amplify Radiation Induced Anti\u2010Tumor Immune Responses"],"prefix":"10.1002","volume":"13","author":[{"given":"Yiyu","family":"Wang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Tropical Disease Control Engineering Research Center for Hainan Bio\u2010Smart Materials and Bio\u2010Medical Devices Key Laboratory of Hainan Functional Materials and Molecular Imaging School of Life 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