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To address these issues, we develop a novel immunoregulatory hydrogel platform based on sodium ascorbate (SA)\u2010accelerated gelation and in situ self\u2010mineralization for facilitating the infected chronic diabetic wound healing. Such a hydrogel is constructed by mixing benzaldehyde\u2010 and cyanoacetate\u2010functionalized dextran with silver nitrate (AgNO\n                    <jats:sub>3<\/jats:sub>\n                    ) and SA, which enables not only the ultrafast solidification but also in situ self\u2010mineralization of silver nanoparticles (Ag NPs). The accelerated gelling properties and ROS\u2010scavenging of the incorporated SA aid in rapid wound closure and oxidative stress alleviation, while the in situ\u2010generated Ag NPs embedded within the hydrogel matrix provide multimodal antibacterial performance, effectively ameliorating inflammatory responses. Thus, when used in an infected diabetic wound model, this immunoregulatory hydrogel platform demonstrates significant facilitation effects for the wound healing by promoting wound closure, alleviating oxidative stress, eradicating bacterial infection, and inhibiting inflammation. These integrated features endow the hydrogels with high value for clinical wound management.\n                  <\/jats:p>","DOI":"10.1002\/advs.75881","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:15:55Z","timestamp":1780064155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sodium Ascorbate\u2010Accelerated Gelling Hydrogels With Rapid Self\u2010Mineralized Capacity for Chronic Wounds"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-5964","authenticated-orcid":false,"given":"Xiaoya","family":"Ding","sequence":"first","affiliation":[{"name":"MOE Innovation Center For Basic Research in Tumor Immunotherapy Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy The First Affiliated Hospital of Anhui Medical University  Hefei 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