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Dealing with the challenge, a novel nanomaterial named TPR\u2010LYTACs has been developed in this study. The TPR\u2010LYTACs construction involves the assembly of a nano\u2010core (TPR) from tea polyphenols and acidified rutin. The antioxidant TPR core is conjugated via modular assembly with a NOX2\u2010targeting antibody and maleylated bovine serum albumin for source inhibition, enabling dual\u2010pathway ROS regulation. In the acute GA model rats, excellent targeting and effective control of local inflammation are demonstrated by the TPR\u2010LYTACs, with near\u2010infrared\u2010II fluorescence imaging confirming their specific enrichment at disease sites. 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