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Through integrative analyses of clinical cohorts and BBN\u2010induced mouse models, we identified KRT14 as a core oncogenic driver that orchestrates the KRT14\u2010IGF2BP1 signaling axis to promote BMIBC progression and lung metastasis. Mechanistically, residues K294 and E295 within the KH2 domain of IGF2BP1 specifically recognize conserved residues D226 and E227 within the nuclear export signal of KRT14. This direct interaction facilitates IGF2BP1\u2010mediated cytoplasmic trafficking and auto\u2010stabilization of its own mRNA, establishing a positive feedback loop that amplifies IGF2BP1\u2010targeted pro\u2010invasive gene expression. Functional disruption of this axis suppressed primary tumor progression and lung metastasis in BMIBC models. Collectively, our findings define the KRT14\u2010IGF2BP1 axis as a previously unrecognized, potentially targetable vulnerability in BMIBC, whose inhibition may limit aggressive disease progression and inform future therapeutic strategies.<\/jats:p>","DOI":"10.1002\/advs.75900","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:45:02Z","timestamp":1781001902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KRT14 Drives Basal Muscle\u2010Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1"],"prefix":"10.1002","volume":"13","author":[{"given":"Shirui","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Oujiang Laboratory Zhejiang Lab for Regenerative Medicine, 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