{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:17:04Z","timestamp":1787912224874,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Precision plant protection requires carriers that couple crystalline order with context\u2010responsive release. Hydrogen\u2010bonded organic frameworks (HOFs) offer ordered, metal\u2010free porosity and programmable host\u2013guest interactions to realize this goal. We therefore built a multi\u2010stimuli\u2010responsive system (PYR@PFC\u20101\u2010F@HACC) using the fluorinated HOF PFC\u20101\u2010F as a pesticide carrier and label\u2010free in planta fluorescent marker. Pyraclostrobin (PYR) was encapsulated in PFC\u20101\u2010F with \u223c30 wt.% loading, and the resulting composite was surface\u2010coated with chitosan quaternary ammonium salt (HACC). The HACC shell imparts leaf adhesion and biointerface compatibility, thereby enabling enzyme\/reactive oxygen species (ROS)\/pH\u2010triggered, site\u2010specific release of the fungicide while suppressing leakage near neutrality. Under pathogen\u2010mimicking conditions, the composite shows hierarchically programmed, multi\u2010stimuli\u2010responsive release with diffusion\u2010dominated kinetics. Antifungal activity follows a dual pathway\u2010membrane disruption together with ROS\u2010associated oxidative stress\u2010accompanied by host\u2010defense remodeling. In planta, the platform curtails lesion development, reduces pathogen adhesion\/invasion, and exhibits robust foliar retention with acropetal transport. Standard biosafety assays show no significant adverse effects at working doses on peanut seed germination, zebrafish, earthworms, or silkworms. Overall, this study delivers a generalizable, sustainable nanocarrier for precision management of soil\u2010borne crop diseases.<\/jats:p>","DOI":"10.1002\/advs.75922","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:05:01Z","timestamp":1780585501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Stimuli\u2010Responsive Hydrogen\u2010Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation"],"prefix":"10.1002","volume":"13","author":[{"given":"Guangming","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity &amp; Key Lab of Biopesticide and Chemical Biology College of Plant Protection Ministry of Education &amp; Ministerial and Provincial Joint Innovation Centre For Safety Production of Cross\u2010Strait Crops Fujian Agriculture and Forestry University  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity &amp; Key Lab of Biopesticide and Chemical Biology College of Plant Protection Ministry of Education &amp; Ministerial and Provincial Joint Innovation Centre For Safety Production of Cross\u2010Strait Crops Fujian Agriculture and Forestry University  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9096-6981","authenticated-orcid":false,"given":"Tianfu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity &amp; Key Lab of Biopesticide and Chemical Biology College of Plant Protection Ministry of Education &amp; Ministerial and Provincial Joint Innovation Centre For Safety Production of Cross\u2010Strait Crops Fujian Agriculture and Forestry University  Fuzhou Fujian P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100880"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8155"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172643"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13080632"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2015.11.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275\u2010021\u20101344\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202506319"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.09.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.13555"},{"key":"e_1_2_9_11_1","first-page":"1","volume-title":"Interface Science and Technology","author":"Nasrollahzadeh M.","year":"2019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC01390E"},{"key":"e_1_2_9_13_1","first-page":"8906","article-title":"Recent Advances in Stimulus\u2010Responsive Nanocarriers for Pesticide Delivery","volume":"72","author":"Ma C.","year":"2024","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115956"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410585"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400101"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2024.11.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308418"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218661"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112796"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.147422"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/toy060"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.159473"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.035"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140968"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.064"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129662"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2023.105682"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118970"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116847"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151901"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5c07904"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icj034"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c02519"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2013.12.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.154844"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c00324"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128051"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140167"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2021.110507"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117058"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142190"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2023.135509"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.07.022"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.9b00303"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406026"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2024.103210"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125380"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147294"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134861"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB01954C"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29225330"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202300756"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1136233"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.158169"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13020128"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/jexbot\/53.372.1331"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.00405"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2021.09.002"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:27:47Z","timestamp":1787909267000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":58,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.75922"],"URL":"https:\/\/doi.org\/10.1002\/advs.75922","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75922"}}