{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:14:24Z","timestamp":1788437664359,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102221\u2010E\u2010002\u2010211\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102221\u2010E\u2010002\u2010211\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102221\u2010E\u2010002\u2010087\u2010MY3"],"award-info":[{"award-number":["112\u20102221\u2010E\u2010002\u2010087\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although the near\u2010infrared (NIR) window is widely recognized for its deep tissue applications, the far\u2010infrared (FIR) region, centered near 10\u00a0\u00b5m, remains largely underexplored. Human skin exhibits a relative absorption minimum in this range, suggesting the potential to deliver thermal energy more deeply while avoiding superficial overheating. Epsilon\u2010near\u2010zero (ENZ) materials provide this capability as their optical resonances confine thermal emission to specific wavelengths. Silicon carbide (SiC) exhibits an ENZ resonance near 10\u00a0\u00b5m, which aligns directly with the FIR skin window. Here, we report the first systematic investigation of wavelength\u2010matched FIR therapy, comparing SiC with the conventional broadband emitter, graphite. A thermally controlled within\u2010subject study of 25 volunteers (50 hands) simultaneously monitored real\u2010time blood perfusion and cardiovascular parameters. After 20 min\u00a0of irradiation, SiC increased cutaneous blood flow by an average of 30.2% relative to baseline, significantly exceeding the 18.6% increase observed with graphite. These enhancements occurred without changes in blood pressure or heart rate, and skin surface temperature remained below 36\u00b0C. These findings establish wavelength\u2010matched FIR therapy as an effective and thermally safe approach for enhancing peripheral circulation without eliciting systemic effects.<\/jats:p>","DOI":"10.1002\/advs.75938","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:51:08Z","timestamp":1781524268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Blood Circulation With Epsilon\u2010Near\u2010Zero (ENZ) Materials via the Far\u2010Infrared Window of Human Skin"],"prefix":"10.1002","volume":"13","author":[{"given":"Wen\u2010Teng","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Medicine MacKay Medical University  Taipei Taiwan"},{"name":"Division of Plastic Surgery Department of Surgery MacKay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Chiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Feng","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine MacKay Medical University  Taipei Taiwan"},{"name":"Division of Plastic Surgery Department of Surgery MacKay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-572X","authenticated-orcid":false,"given":"Hsuen\u2010Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National Taiwan University  Taipei Taiwan"},{"name":"Center of Atomic Initiative for New Materials National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010017\u20100478\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000470"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/plm\u20102012\u20100034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2017.1414142"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121577"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9tc04690a"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050557\u2010w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114821"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.09.035"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.110"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.28.545"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.3c02619"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1304081"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.2c00464"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050534"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100781.2006.00208.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201048187\u20100"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2025.100900"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42005\u2010024\u201001888\u2010z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.8b00565"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201049897\u20102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.5b00140"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309330"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1364\/prj.427246"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.100.033903"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.97.157403"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2017.13"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045054\u2010z"},{"issue":"6287","key":"e_1_2_9_30_1","first-page":"795","article-title":"Large Optical Nonlinearity of Indium Tin Oxide in Its Epsilon\u2010Near\u2010Zero Region","volume":"352","author":"Zahirul Alam M.","year":"2016","journal-title":"Scientific Reports"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201205076"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2006.11.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.21.000A96"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01184"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.3c00476"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevApplied.13.064073"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1515\/nanoph\u20102022\u20100047"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00269"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2024.11.050"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2023.04.071"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.04.014"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067220\u20105"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.93.085205"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.369370"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.75938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.75938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:23:53Z","timestamp":1788434633000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.75938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":43,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.75938"],"URL":"https:\/\/doi.org\/10.1002\/advs.75938","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75938"}}