{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:17:16Z","timestamp":1787912236216,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203154"],"award-info":[{"award-number":["52203154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Using nutrients to modulate anti\u2010tumor immunity offers clear advantages over developing new immunotherapy drugs, yet its clinical translation is hampered by low oral delivery efficiency. Herein, we propose concept of nano\u2010nutritional medicine (NNM), encapsulating IR780 in lipid nanoparticles (IR780@TVA LNPs) containing a eutectic mixture of\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010vaccenic acid (TVA) and stearic acid. Eutectic mixture (melting point: 40.5\u00b0C) functions as gated phase\u2010change material, triggered by near\u2010infrared light to release TVA. Compared to oral free TVA, IR780@TVA LNPs increase intratumoral TVA concentration by 21.86\u2010fold. IR780@TVA LNPs demonstrate excellent photothermal ablation and induce adaptive immunity. Subsequently, the released TVA not only reduces CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell exhaustion by activating cAMP\u2010PKA\u2010CREB axis, but downregulates PD\u20101 levels in T cells and upregulates PD\u2010L1 levels in tumor cells, thereby potentiating PD\u2010L1 blockade therapy in both \u201chot\u201d and \u201ccold\u201d tumor models, achieving complete responses in some instances. These cured mice establish long\u2010term immune memory, enabling them to resist tumor rechallenge. Furthermore, IR780@TVA LNPs suppress advanced large tumors and prevent lung metastasis, demonstrating superior efficacy compared to first\u2010line therapy (radiotherapy + PD\u2010L1 blockade). Overall, this work establishes first platform for targeted delivery and on\u2010demand release of dietary immunonutrients, paving the way for NNM as a new direction in cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.75992","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:00:21Z","timestamp":1781002821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward Nano\u2010Nutritional Medicine: A Remotely Activated\n                    <i>Trans<\/i>\n                    \u2010Vaccenic Acid\u2010Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Kang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer science and Technology (Changchun Institute of Applied Chemistry Chinese Academy of Sciences)  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanwei","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-044X","authenticated-orcid":false,"given":"Song","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-4206","authenticated-orcid":false,"given":"Ye","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"She","sequence":"additional","affiliation":[{"name":"The Seventh Affiliated Hospital of Sun Yat\u2010Sen University, Department of Orthopedics  Guangming District Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-9034","authenticated-orcid":false,"given":"Dengke","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application  Hefei China"},{"name":"Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department (AUCM)  Hefei China"},{"name":"Anhui Provincial Key Laboratory of Chinese Medicinal Formula  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7308-4589","authenticated-orcid":false,"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"Key Laboratory of Xin'an Medicine (Anhui University of Chinese Medicine)  Hefei P. 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