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Here, we found that the chemokine CCL3 plays a significant role in modulating intratumoral T cell cytotoxicity. However, CCL3 alone is insufficient to sustain durable CAR\u2010T cell\u2010mediated tumor killing, largely due to tumor\u2010induced T cell death. In contrast, the combination of CCL3 with interleukin\u20107 (IL\u20107), a cytokine known to enhance T cell survival, exerted a potent synergistic effect. This combination significantly improved CAR\u2010T cell infiltration and longevity in solid tumors, leading to robust anti\u2010tumor efficacy without significant side effects or systemic toxicity. Mechanistically, CCL3 plus IL\u20107 promoted RUNX3 expression and facilitated the differentiation of CD69\n                    <jats:sup>+<\/jats:sup>\n                    CD103\n                    <jats:sup>+<\/jats:sup>\n                    tissue\u2010resident memory T (Trm) cells. Furthermore, treatment with CAR\u2010T cells co\u2010expressing CCL3 and IL\u20107 (3P7\u2010CAR\u2010T) remodeled the immune landscape of solid tumors, marked by an increased infiltration of M1\u2010like macrophages and CD103\n                    <jats:sup>+<\/jats:sup>\n                    migratory dendritic cells. These changes enhance antigen presentation, thereby promoting the priming of endogenous anti\u2010tumor T cell responses. Taken together, our results demonstrate that CCL3 synergizes with IL\u20107 to augment CAR\u2010T cell memory and therapeutic effectiveness in solid tumors.\n                  <\/jats:p>","DOI":"10.1002\/advs.75993","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:54:34Z","timestamp":1782125674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CCL3 and IL\u20107 Synergistically Enhance CAR\u2010T Efficacy in Solid Tumors"],"prefix":"10.1002","volume":"13","author":[{"given":"Huanpeng","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University Guangzhou National Laboratory Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangzhou National Laboratory Guangzhou International Bio\u2010Island  Guangzhou Guangdong 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