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These wounds are characterized by mature biofilms reinforced by dense extracellular polymeric substances, which confer strong tolerance to conventional treatments. Despite emerging technologies, such as nanoparticles, bacteriophages, and engineered enzymes, effective clearance of established biofilms remains challenging. Here, we develop a microblasting wound dressing (\u00b5BLAST) that delivers spatially confined mechano\u2010chemical disruption at the tissue\u2010biofilm interface to remove viscoelastic biofilm matrices and promote tissue regeneration. The \u00b5BLAST is assembled by embedding MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010doped diatom biosilica beneath an H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010releasing cellulose mesh, enabling localized catalytic microbubble generation within biofilm matrices. Confined expansion and rupture of oxygen bubbles produce localized mechanical stress sufficient to dislodge mature, antibiotic\u2010resistant polymicrobial biofilms, while sustained H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    release prolongs particle activity. In a murine wound model infected with mature\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    and methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    biofilms, \u00b5BLAST treatment significantly reduces biofilm burden, accelerates re\u2010epithelialization, promotes hair regrowth, and mitigates inflammation. Moreover, \u00b5BLAST enhances antibiotic efficacy, suppressing biofilm regrowth even at ten\u2010fold reduced drug doses. These findings highlight confined mechano\u2010chemical biofilm disruption as a therapeutic strategy for treating mature, antibiotic\u2010resistant biofilm infections and promoting tissue regeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.75999","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:55:45Z","timestamp":1781085345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment\u2010Resistant Wounds"],"prefix":"10.1002","volume":"13","author":[{"given":"Yujin","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Chan Zuckerberg Biohub Chicago  Chicago Illinois 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Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A.","family":"Markowicz","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois 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