{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:04:18Z","timestamp":1789376658591,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20378"],"award-info":[{"award-number":["U20A20378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82188102"],"award-info":[{"award-number":["82188102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273488"],"award-info":[{"award-number":["82273488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100645"],"award-info":[{"award-number":["82100645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573472"],"award-info":[{"award-number":["82573472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer vaccines have demonstrated initial effectiveness in the treatment of human cancers, still the low mutational burden, which leads to a deficiency of well\u2010characterized antigens expressed within tumors capable of mediating tumor rejection, poses a significant challenge in pancreatic cancer. Here, we introduce an ionic liquid ILvax for localized tumor administration, which elicits a systemic and antigen\u2010specific anti\u2010tumor immune response, thereby generating a vaccine\u2010like effect. Type 1 conventional dendritic cells (cDC1) is the determinant for systemic immune response. ILvax ablation facilitates migration of tumor antigen\u2010carrying cDC1 to peripheral lymphoid organs, thus initiating the cDC1\u2010mediated antigen presentation cascade that results in an amplified antigen\u2010specific T cells response. Meanwhile, cDC1\u2010mediated antigen spreading induced by ILvax enabled the expansion of adoptive TCR\u2010T while shifting TCR\u2010T metabolism toward oxidative phosphorylation (OXPHOS). Localized tumor administration with ILvax simultaneously enhances the functionality of both endogenous CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and adoptive TCR\u2010T cells, offering a clinically translatable collaborative strategy against pancreatic cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.76135","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:59:22Z","timestamp":1781859562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antigen Spreading via Localized Administration Enhances Adoptive TCR\u2010T Cell Therapy in Pancreatic Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Junming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5552-2567","authenticated-orcid":false,"given":"Zhuo","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Breast Surgery the First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-9725","authenticated-orcid":false,"given":"Tingbo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Breast Surgery the First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou Zhejiang China"},{"name":"The Innovation Center For the Study of Pancreatic Diseases  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9092-7808","authenticated-orcid":false,"given":"Qida","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease School of Medicine the First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.04.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.08.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001561\u20106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.06.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201035130\u20107"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010021\u201000346\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw261"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20100305"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001784\u20101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010024\u201002898\u2010y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102023\u2010006896"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171621"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206756"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19462"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0184-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001723\u2010z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq3016"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.12.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5967"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002612\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn2231"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.07.021"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033968\u20105"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe3889"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100410\u2010x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18300"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307193"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305361"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000463\u2010z"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102229\u20105"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14169"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039759\u2010w"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051722\u2010x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.03.019"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.07.002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav8692"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:23:41Z","timestamp":1789374221000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":39,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.76135"],"URL":"https:\/\/doi.org\/10.1002\/advs.76135","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2026-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76135"}}