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While microenvironment\u2010responsive implantable drug delivery systems can achieve various long\u2010term release patterns, they offer only passive, non\u2011programmable profiles. Light\u2010controlled strategies enable precise external regulation but face two critical barriers: the lack of integrated devices combining stable drug reservoirs with implantable light platforms, and the inherent light\u2013release coupling of conventional phototriggered systems that necessitates continuous illumination for sustained dosing. Here, we develop an implantable phototriggered prodrug depot patch (iPDP) enabling actively programmable drug release after implantation. The iPDP fuses a phototriggered sustained\u2010release prodrug hydrogel (GTel\u2011hydrogel) and a percutaneous light\u2011guiding device. The prodrug GTel features a self\u2010immolative linker, allowing a brief optical trigger to initiate sustained, light\u2011independent release. The covalently conjugated prodrug ensures minimal leakage, with dose per release precisely controlled by illumination parameters (intensity\/duration) as the programming code. In a rat MI model, the iPDP delivered a triple\u2011dose, actively programmed regimen. Compared with a single release of an equivalent total dose, this fractionated programmed strategy showed superior efficacy in improving cardiac function and suppressing inflammation. The iPDP enables post\u2011implantation active control from a single device, offering a promising strategy for long\u2010term dynamic post\u2010MI therapy.<\/jats:p>","DOI":"10.1002\/advs.76161","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:11:07Z","timestamp":1782475867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post\u2010Myocardial Infarction Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Haipeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Transvascular Implantation Devices Heart Regeneration and Repair Key Laboratory of Zhejiang Province The Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou China"},{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaicheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Transvascular Implantation Devices Heart Regeneration and Repair Key Laboratory of Zhejiang Province The Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou China"},{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou 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