{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:03:48Z","timestamp":1789376628227,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472066"],"award-info":[{"award-number":["82472066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272087"],"award-info":[{"award-number":["82272087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515020055"],"award-info":[{"award-number":["2021B1515020055"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB26153"],"award-info":[{"award-number":["20242BAB26153"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Perineural invasion (PNI) is common in gastric cancer and predicts poor prognosis, but the molecular mechanisms underlying tumour\u2013nerve crosstalk remain unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Transcriptomic data from TCGA and GEO were integrated to identify PNI regulators, with validation in surgical specimens. Mechanistic studies used tumor\u2013neuron Transwell co\u2010culture, siRNA\/lentiviral perturbation, Western blot, immunofluorescence, ELISA, co\u2010immunoprecipitation, and GST pull\u2010down. Functional effects were assessed via CCK\u20108\/Transwell assays, a sciatic nerve invasion xenograft model, and an orthotopic gastric cancer model with neuron\u2010specific MIF conditional knockout mice.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : High CXCL8\/VCAM1 expression correlates with poor overall survival, distant metastasis, and is upregulated in PNI\u2010positive tumours. Mechanistically, CXCL8 promotes neuronal MIF expression, while MIF directly binds VCAM1 and enhances tumour CXCL8 expression. VCAM1\u2010mediated CXCL8 upregulation drives tumour proliferation and invasion. In vivo, blocking CXCL8\/VCAM1 or neuron\u2010specific MIF deletion reduces tumour growth and neural invasion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : A MIF\u2013VCAM1\u2013CXCL8 positive\u2010feedback axis linking neural activity to gastric cancer progression and PNI is identified, providing prognostic biomarkers and actionable therapeutic targets.\n                  <\/jats:p>","DOI":"10.1002\/advs.76195","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:44:52Z","timestamp":1782157492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuron\u2010Derived MIF Engages VCAM1 to Fuel a Self\u2010Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-3733","authenticated-orcid":false,"given":"Xunjun","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery &amp; 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Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang Hospital Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery &amp; Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang Hospital Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-5628","authenticated-orcid":false,"given":"Luxi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Thyroid And Breast Surgery Shenzhen Hospital Southern Medical University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery &amp; 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