{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:30:08Z","timestamp":1786476608414,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The previous study elucidated that the C\u2010reactive protein (CRP)\/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis\u2010associated anxiety\u2010like behaviors in rats. This molecular crosstalk along the periodontal\u2010hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed regarding the establishment of the core finding linking peripheral inflammation to emotional disorders and potential translational significance. Here, this commentary analyzes the mechanisms underlying CRP entry into the brain, the choice of behavioral paradigms for emotional assessment, the possible dynamic evolution of the pathogenesis, and the translational potential of CRP, with the aim of fostering constructive academic discussion.<\/jats:p>","DOI":"10.1002\/advs.76215","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:48:29Z","timestamp":1781858909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety\u2010Like Behaviors"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-2815","authenticated-orcid":false,"given":"Zhigang","family":"Chen","sequence":"first","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13395"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406269"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202516199"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13281"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052727\u20102"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.04.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.11.022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201044205\u2010y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010024\u201002244\u20109"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12568"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:03:09Z","timestamp":1786474989000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":10,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.76215"],"URL":"https:\/\/doi.org\/10.1002\/advs.76215","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76215"}}